Publication: Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection
dc.contributor.author | Habip, Z. | |
dc.contributor.author | Sohrabi, P. | |
dc.contributor.author | Saribas, S. | |
dc.contributor.author | Caliskan, R. | |
dc.contributor.author | Demirci, M. | |
dc.contributor.author | Karakullukcu, A. | |
dc.contributor.author | Atalik, K. | |
dc.contributor.author | Yuksel, P. | |
dc.contributor.author | Uysal, ÖMER | |
dc.contributor.author | Kosan, E. | |
dc.contributor.author | Tokman, H. Bahar | |
dc.contributor.author | Kocazeybek, B. | |
dc.contributor.institutionauthor | YÜKSEL MAYDA, PELİN | |
dc.contributor.institutionauthor | UYSAL, ÖMER | |
dc.date.accessioned | 2019-10-05T14:20:02Z | |
dc.date.available | 2019-10-05T14:20:02Z | |
dc.date.issued | 2017-01-01 | |
dc.description.abstract | Neopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity group (LRG, n: 70), true positive HCV infection group (THG, 30) and healthy control group (HCG, 30) were analyzed in this study. We have used ELISA, HCV RIBA/LIA and HCV-RNA methods. Mean neopterin levels were significantly lower in LRG than THG (p 0.05). Mean sCD14 were significantly higher in LRG than THG and HCG (p <0.05, p <0.001). Values of 3.95 mu g/ml and 5.36 nmol/l for sCD14 and neopterin resulted in the maximum area under the receiver operating characteristic curves (ROC), which were 0.859 (95% CI, 0.745 to 0.935; <0.0001) and 0.788 (95% CI, 0.663 to 0.883; <0.0001), respectively. These cut-offs corresponded to a sensitivity of 73.3% and a specificity of 73.3% for neopterin and of 100% and 76.7% for sCD14. Our results suggest that a specific immunoactivation might be caused by true positive HCV infection. Due to the significant results sCD14 in LRG might be non-specifically affected by some underlying atypical immunohematological pathologies. Only neopterin might be used to exclude low anti-HCV reactivity from a true HCV infection. The use of neopterin but not sCD14 in combination with fourth-generation EIA/CMIA combo tests will be useful when nucleic acid tests are not available for screening blood donors at blood banks. | |
dc.description.sponsorship | İstanbul Üniversitesi | |
dc.identifier | 10.1111/j.1750-3841.2011.02142.x | |
dc.identifier.citation | Habip Z., Sohrabi P., Saribas S., Caliskan R., Demirci M., Karakullukcu A., Atalik K., Yuksel P., Uysal Ö., Kosan E., et al., -Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection-, ACTA VIROLOGICA, cilt.61, ss.264-272, 2017 | |
dc.identifier.doi | 10.4149/av_2017_304 | |
dc.identifier.scopus | 85028602483 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/3582 | |
dc.identifier.wos | WOS:000411298700005 | |
dc.language.iso | en | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | JOURNAL OF FOOD SCIENCE | |
local.avesis.id | 5713e983-5252-4ed4-a19b-42f80d9ec685 | |
local.avesis.response | 3452 | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.org.faculty | Tıp Fakültesi | |
local.publication.goal | 03 - Sağlık ve Kaliteli Yaşam | |
local.publication.isinternational | 1 | |
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