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Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection

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dc.contributor.authorHabip, Z.
dc.contributor.authorSohrabi, P.
dc.contributor.authorSaribas, S.
dc.contributor.authorCaliskan, R.
dc.contributor.authorDemirci, M.
dc.contributor.authorKarakullukcu, A.
dc.contributor.authorAtalik, K.
dc.contributor.authorYuksel, P.
dc.contributor.authorUysal, ÖMER
dc.contributor.authorKosan, E.
dc.contributor.authorTokman, H. Bahar
dc.contributor.authorKocazeybek, B.
dc.contributor.institutionauthorYÜKSEL MAYDA, PELİN
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T14:20:02Z
dc.date.available2019-10-05T14:20:02Z
dc.date.issued2017-01-01
dc.description.abstractNeopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity group (LRG, n: 70), true positive HCV infection group (THG, 30) and healthy control group (HCG, 30) were analyzed in this study. We have used ELISA, HCV RIBA/LIA and HCV-RNA methods. Mean neopterin levels were significantly lower in LRG than THG (p 0.05). Mean sCD14 were significantly higher in LRG than THG and HCG (p <0.05, p <0.001). Values of 3.95 mu g/ml and 5.36 nmol/l for sCD14 and neopterin resulted in the maximum area under the receiver operating characteristic curves (ROC), which were 0.859 (95% CI, 0.745 to 0.935; <0.0001) and 0.788 (95% CI, 0.663 to 0.883; <0.0001), respectively. These cut-offs corresponded to a sensitivity of 73.3% and a specificity of 73.3% for neopterin and of 100% and 76.7% for sCD14. Our results suggest that a specific immunoactivation might be caused by true positive HCV infection. Due to the significant results sCD14 in LRG might be non-specifically affected by some underlying atypical immunohematological pathologies. Only neopterin might be used to exclude low anti-HCV reactivity from a true HCV infection. The use of neopterin but not sCD14 in combination with fourth-generation EIA/CMIA combo tests will be useful when nucleic acid tests are not available for screening blood donors at blood banks.
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier10.1111/j.1750-3841.2011.02142.x
dc.identifier.citationHabip Z., Sohrabi P., Saribas S., Caliskan R., Demirci M., Karakullukcu A., Atalik K., Yuksel P., Uysal Ö., Kosan E., et al., -Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection-, ACTA VIROLOGICA, cilt.61, ss.264-272, 2017
dc.identifier.doi10.4149/av_2017_304
dc.identifier.scopus85028602483
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3582
dc.identifier.wosWOS:000411298700005
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleNeopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF FOOD SCIENCE
local.avesis.id5713e983-5252-4ed4-a19b-42f80d9ec685
local.avesis.response3452
local.org.facultyTıp Fakültesi
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationa7da1ef6-442b-46fc-8c6c-601442ec1778
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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