Maternal serum preptin levels in the pathogenesis and diagnosis of Gestational diabetes mellitus.

Abstract

Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating levels of preptin, a new peptide secreted from pancreatic beta cells, due to GDM in pregnant women. The relationship between serum preptin levels with insulin and other metabolic parameters was also evaluated in these subjects.

Eighty-five patients diagnosed as GDM and 89 healthy pregnant women with 75 mg oral glucose tolerance test (OGTT) was assessed in terms of serum preptin levels.

The serum preptin levels of the GDM group were significantly higher than those of the control group (p=0.001; p < 0.01). For the cutoff value of preptin measurement of 335.3 ng/L, the sensitivity was 97.65%, specificity was 87.64%, positive predictive value was 88.3% and negative predictive value was 97.5%. The risk of developing the disease is 294.273 times higher in patients with preptin level of 335.3 and above.

We think that the reason for the increase in serum preptin levels in GDM is probably the response to glucose. The current results indicate that preptin plays an important role in elucidating the pathology of GDM. In addition, the search for a practical marker for the diagnosis of GDM suggests that the measurement of preptin level is promising.

Gestacijski dijabetes melitus (GDM) je metabolički poremećaj koji se javlja tokom trudnoće i povećava smrtnost i morbiditet i majke i fetusa. Ispitivano je da li po stoji promena u cirkulišućim nivoima preptina, novog peptida izlučenog iz beta ćelija pankreasa, usled GDM kod trudnica. Odnos između nivoa preptina u serumu sa insulinom i drugih metaboličkih parametara je takođe procenjen kod ovih ispitanika.

Osamdeset pet pacijenata sa dijagnozom GDM i 89 zdravih trudnica sa 75 mg oralnim testom tolerancije glukoze (OGTT) je procenjeno u smislu nivoa preptina u serumu.

Nivoi preptina u serumu GDM grupe bili su značajno viši od onih u kontrolnoj grupi (p=0,001; p < 0,01). Za graničnu vrednost merenja preptina od 335,3 ng/L, osetljivost je bila 97,65%, specifičnost je bila 87,64%, pozitivna prediktivna vrednost je bila 88,3% i negativna prediktivna vrednost je bila 97,5%. Rizik od razvoja bolesti je 294.273 puta veći kod pacijenata sa nivoom preptina od 335,3 i više.

Smatramo da je razlog za povećanje nivoa serumskog preptina u GDM verovatno odgovor na glukozu. Sadašnji rezultati pokazuju da preptin igra važnu ulogu u rasvetljavanju patologije GDM. Pored toga, potraga za praktičnim markerom za dijagnozu GDM-a sugeriše da je merenje nivoa preptina obećavajuće.