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Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.

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dc.contributor.authorSahbaz, C
dc.contributor.authorElbay, AHMET
dc.contributor.authorOzcelik, M
dc.contributor.authorOzdemir, H
dc.contributor.institutionauthorELBAY, AHMET
dc.contributor.institutionauthorÖZDEMİR, MEHMET HAKAN
dc.date.accessioned2020-04-27T20:59:05Z
dc.date.available2020-04-27T20:59:05Z
dc.date.issued2020-03-19T00:00:00Z
dc.description.abstractSleep may play a fundamental role in retinal regulation and the degree of retinal variables. However, no clinical study has investigated optical coherence tomography (OCT) parameters in patients with primary insomnia. All participants were evaluated with the insomnia severity index (ISI) and the Pittsburgh sleep quality index (PSQI). The retinal nerve fiber layer (RNFL), ganglion cell layer (GC), inner plexiform layer (IPL), macula and choroidal (CH) thickness were compared between 52 drug-naïve patients with primary insomnia and 45 age-gender-BMI-smoke status matched healthy controls (HC). The patients with primary insomnia differed from the HC regarding RNFL-Global (p = 0.024) and RNFL-Nasal inferior (p = 0.010); IPL-Temporal (p < 0.001), IPL-Nasal (p < 0.001); CH-Global (p < 0.001), CH-Temporal (p = 0.004), CH-Nasal (p < 0.001), and CH-Fovea (p = 0.019). ISI correlated with RNFL-Global and RNFL-Nasal inferior. The regression analysis revealed that ISI was the significant predictor for the thickness of RNFL- Nasal inferior (p = 0.020), RNFL-Global (p = 0.031), and CH-Nasal (p = 0.035) in patients with primary insomnia. Sleep disorders are seen commonly in patients with psychiatric, including ocular diseases. Adjusting the effect of insomnia can help to clarify the consistency in findings of OCT.en
dc.identifier.citationSahbaz C., Elbay A., Ozcelik M., Ozdemir H., -Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.-, Brain sciences, cilt.10, 2020
dc.identifier.doi10.3390/brainsci10030178
dc.identifier.pubmed32204463
dc.identifier.scopus85082681126
dc.identifier.urihttps://hdl.handle.net/20.500.12645/16446
dc.identifier.wosWOS:000524314600031
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleInsomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7d92968e-f666-4e7c-b4d7-56d6dbce6400
local.publication.isinternational1
relation.isAuthorOfPublication7a25551f-eebe-44b4-8dd9-95bc4f53bac1
relation.isAuthorOfPublication9060b30f-7577-47e2-8bee-b2e001a19e7f
relation.isAuthorOfPublication.latestForDiscovery7a25551f-eebe-44b4-8dd9-95bc4f53bac1
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