Publication:
Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model

Simple item page
dc.contributor.authorKeles, Gonca Cayir
dc.contributor.authorBalli, UMUT
dc.contributor.authorCetinkaya, Burcu Ozkan
dc.contributor.authorAyas, Bulent
dc.contributor.authorFindik, Arzu
dc.contributor.authorKeles, Zeynep Pinar
dc.contributor.authorPamuk, Ferda
dc.contributor.institutionauthorBALLI, UMUT
dc.date.accessioned2021-02-01T20:59:45Z
dc.date.available2021-02-01T20:59:45Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractObjective. Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. Methods. Thirty rats were randomly divided into three groups of ten animals each: ligature-induced experimental periodontitis groups (with 10-day (Group1) and 40-day periods (Group2)) and healthy group (Group3). At the end of experimental period, rats were sacrificed, and radiological and histomorphometric analyses were performed on the mandibles. PTX3 levels were measured in gingival tissue and serum samples using ELISA. Plasma fibrinogen levels were measured according to the nephelometric method. Results. Significant alveolar bone resorption and periodontal inflammation were evident in periodontitis groups. Levels of PTX3 in gingival tissue were statistically higher in Group 1 than those in groups 2 and 3 (P 0.05). Plasma fibrinogen levels were significantly increased in the experimental periodontitis groups (P < 0.001). Conclusion. PTX3 seems to be associated with tissue destruction in earlier periods of inflammatory periodontal disease, contrary to the fibrinogen findings.
dc.identifier.citationKeles G. C. , Balli U., Cetinkaya B. O. , Ayas B., Findik A., Keles Z. P. , Pamuk F., -Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model-, MEDIATORS OF INFLAMMATION, cilt.2012, 2012
dc.identifier.doi10.1155/2012/809801
dc.identifier.scopus84866058224
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28256
dc.identifier.wosWOS:000308155000001
dc.titleBiochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model
dc.typeArticle
dspace.entity.typePublication
local.avesis.id94322a39-c878-48d4-808d-0f7836d2ec2e
local.publication.isinternational1
relation.isAuthorOfPublication98da5869-ea4b-40c5-873f-9bbd29c50a23
relation.isAuthorOfPublication.latestForDiscovery98da5869-ea4b-40c5-873f-9bbd29c50a23
Files
Collections
Silinecekler