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EFFECTS OF ACETYLCHOLINESTERASE INHIBITORS ON NUTRITIONAL STATUS IN ELDERLY PATIENTS WITH DEMENTIA: A 6-MONTH FOLLOW-UP STUDY

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dc.contributor.authorSoysal, PINAR
dc.contributor.authorIsik, A. T.
dc.contributor.institutionauthorSOYSAL, PINAR
dc.date.accessioned2020-10-29T13:08:36Z
dc.date.available2020-10-29T13:08:36Z
dc.date.issued2016-04-01T00:00:00Z
dc.description.abstractObjectives: Nutritional status is one of the factors that affects disease progression, morbidity and mortality in elderly patients with dementia. The present study aimed to evaluate the effect of acetylcholinesterase inhibitor (AchEI) therapy on nutritional status and food intake in the elderly. Design, setting and participants: Newly diagnosed patients with dementia, who underwent comprehensive geriatric assessment (CGA) and were followed at regular intervals, were retrospectively evaluated. A total of 116 patients, who began to receive AchEI therapy and completed 6-month follow-up period under this treatment, were enrolled in the study. Measurements: Socio-demographic characteristics and data on comorbidity, polypharmacy, cognitive function, depression, activities of daily living and nutritional status (weight, Body Mass Index (BMI), Mini Nutritional Assessment (MNA)-Short Form) were recorded. Results: The mean age of the patients was 78.0 +/- 8.9 years. There was no significant difference between baseline and 6-month BMI, weight and MNA scores of dementia patients who received AchEI therapy (p>0.05). With regard to the relation between changes in BMI, weight and MNA on the 6th month versus baseline, and donepezil, rivastigmine and galantamine therapies, no difference was determined (p>0.05). However, no worsening in food intake was observed (kappa: 0.377). When the effects of each AchEI on food intake were compared, food intake in rivastigmine treated patients was not decreased as much as it was in galantamine or donepezil treated patients (p<0.05). Conclusion: AchEI therapy has no unfavorable effect on nutritional status or weight in elderly patients with different types of dementia, but it seems that food intake is better in those treated by rivastigmine patch.
dc.identifier.citationSoysal P., Isik A. T. , -EFFECTS OF ACETYLCHOLINESTERASE INHIBITORS ON NUTRITIONAL STATUS IN ELDERLY PATIENTS WITH DEMENTIA: A 6-MONTH FOLLOW-UP STUDY-, JOURNAL OF NUTRITION HEALTH & AGING, cilt.20, ss.398-403, 2016
dc.identifier.doi10.1007/s12603-015-0603-z
dc.identifier.scopus84944706493
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25096
dc.identifier.wosWOS:000374702200005
dc.titleEFFECTS OF ACETYLCHOLINESTERASE INHIBITORS ON NUTRITIONAL STATUS IN ELDERLY PATIENTS WITH DEMENTIA: A 6-MONTH FOLLOW-UP STUDY
dc.typeArticle
dspace.entity.typePublication
local.avesis.id086c8937-adb9-40b6-a7b2-6b508b661341
local.publication.isinternational1
relation.isAuthorOfPublication0e36986e-d71d-4579-a395-877af097ade5
relation.isAuthorOfPublication.latestForDiscovery0e36986e-d71d-4579-a395-877af097ade5
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