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Extractive Spectrophotometric Method for the Determination of Lamivudine and Zidovudine in Pharmaceutical Preparations Using Bromocresol Purple

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dc.contributor.authorTekkeli, Serife Evrim Kepekci
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.date.accessioned2019-10-05T13:47:44Z
dc.date.available2019-10-05T13:47:44Z
dc.date.issued2013-01-01
dc.description.abstractA new spectrophotometric method has been established for the quantitation of lamivudine (LVD) and zidovudine (ZVD) in pharmaceutical preparations. The method is based on the reaction between the investigated drug substances and bromocresol purple (BCP) producing ion-pair complexes in acidic buffers which are suitable for chloroform extraction. The maximum absorbance of these complexes was measured at 424 nm in chloroform. All variables were studied to optimize the reaction conditions. Linearity ranges were found to be 25-250 mu g mL(-1) for LVD-BCP and 50-300 mu g mL(-1) for ZVD-BCP. The developed method was successfully applied for the determination of these drugs in pharmaceutical preparations. Excipients in pharmaceutical formulations did not interfere in the analysis. The results were compared statistically with those obtained by the HPLC method reported in the literature. According to the results, the proposed method can be recommended for quality control and routine analysis.
dc.identifier10.3109/03630269.2014.951890
dc.identifier.citationTekkeli S. E. K. , -Extractive Spectrophotometric Method for the Determination of Lamivudine and Zidovudine in Pharmaceutical Preparations Using Bromocresol Purple-, JOURNAL OF CHEMISTRY, 2013
dc.identifier.doi10.1155/2013/484389
dc.identifier.scopus84884228408
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3018
dc.identifier.urihttps://www.hindawi.com/journals/jchem/2013/484389/
dc.identifier.wosWOS:000324128900001
dc.language.isoen
dc.subjectBromocresol Purple
dc.titleExtractive Spectrophotometric Method for the Determination of Lamivudine and Zidovudine in Pharmaceutical Preparations Using Bromocresol Purple
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameHemoglobin
local.avesis.id494b2140-ae29-4644-9913-618f2758672d
local.avesis.response2888
local.org.facultyTıp Fakültesi
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication.latestForDiscovery837d5047-762e-43db-b252-9f3d1399378f
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