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New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.

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dc.contributor.authorAKTHSR, Muhammad Salman
dc.contributor.authorSÖNMEZ, FATMA CAVİDE
dc.contributor.authorYILDIZ, PELİN
dc.contributor.authorTANRIKULU, MEHMET AKİF
dc.contributor.authorAYDIN, CEMALETTİN
dc.contributor.authorKAHRAMAN AY, NURAY
dc.contributor.institutionauthorSÖNMEZ, FATMA CAVİDE
dc.contributor.institutionauthorYILDIZ, PELİN
dc.contributor.institutionauthorAYDIN, CEMALETTİN
dc.contributor.institutionauthorKAHRAMAN AY, NURAY
dc.date.accessioned2019-10-05T12:56:05Z
dc.date.available2019-10-05T12:56:05Z
dc.date.issued2016-12-01
dc.description.abstractBACKGROUND Current research investigating the role of THBS2 and LECT-2 in atherogenesis is very limited. Therefore, we designed this study to demonstrate the role of THBS-2 and LECT-2 in atherosclerosis at the tissue level in fresh specimens. MATERIAL AND METHODS A total of 32 patients who underwent coronary bypass surgery were enrolled. Aortic wall punch biopsies were obtained at the site of proximal aortosaphenous bypass graft anastomosis. A specimen of left internal mammarian artery (LiMA) was taken from the segment just proximal to its anastomosis. The aortic tissue is representive of the atherosclerotic tisue, and LiMA tissue is representative of the non-atherosclerotic area. The specimens were painted with CD68 for macrophage, and THBS-2 and LECT-2 antibodies for immunohistochemical staining. RESULTS Aortic THBS-2 levels were significantly lower, whereas aortic LECT-2 levels were significantly higher when compare to LiMA (14.4±9.9 (5-30) and 36.9±13.0 (5-60) p: 0.0001 and 20.3±15.0 (5-60) and 20.8±13,8 (10-30) p: 0.0001, respectively). CD68+ and monocyte level correlated significantly with AHA atherosclerosis grade (p=0.01, r=0.45 and p=0.001, r=0.56, Spearman's test). CD68+ level correlated significantly with LECT-2 levels in atherosclerotic aortic tissue (p=0.026, r=0.392, Spearman's test), whereas aortic TSBN-2 levels were not. CONCLUSIONS The present study has taken the first steps to highlight new markers in atherosclerosis by using immunohistochemical method. The study results suggest that the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis.en
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dc.identifier.citationSÖNMEZ F. C. , YILDIZ P., AKTHSR M. S. , AYDIN C., SÖNMEZ O., KAHRAMAN AY N., TANRIKULU M. A. , -New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.-, MEDICAL SCIENCE MONITOR, ss.5234-5239, 2016
dc.identifier.doi10.12659/msm.898889
dc.identifier.pubmed28039493
dc.identifier.scopus85008335009
dc.identifier.urihttps://hdl.handle.net/20.500.12645/961
dc.identifier.wosWOS:000391382300001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleNew Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL JOURNAL OF CLINICAL PHARMACY
local.avesis.id15f21da7-2514-4f88-bc05-de3ab45fecdc
local.avesis.response831
local.publication.isinternational1
relation.isAuthorOfPublicationf2e28f00-b1be-4efc-a354-4b184e0989bf
relation.isAuthorOfPublication4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isAuthorOfPublicationdddd24eb-26e1-424e-b73b-9cf85751a6a4
relation.isAuthorOfPublicationd80356ae-8a57-4abe-ab5d-2700923b668d
relation.isAuthorOfPublication.latestForDiscoveryd80356ae-8a57-4abe-ab5d-2700923b668d
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