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Somatostatin Analogs Regress Endometriotic Implants in Rats by Decreasing Implant Levels of Vascular Endothelial Growth Factor and Matrix Metaloproteinase 9

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dc.contributor.authorSevket, OSMAN
dc.contributor.authorSEVKET, Asli
dc.contributor.authorMOLLA, Taner
dc.contributor.authorBuyukpinarbasili, NUR
dc.contributor.authorUysal, Omer
dc.contributor.authorYILMAZ, Bulent
dc.contributor.authorDANE, Banu
dc.contributor.authorKELEKCI, Sefa
dc.contributor.institutionauthorŞEVKET, OSMAN
dc.contributor.institutionauthorBÜYÜKPINARBAŞILI, NUR
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T21:10:59Z
dc.date.available2019-10-05T21:10:59Z
dc.date.issued2013-06-01
dc.description.abstractObjective: To examine the effect of somatostatin analogs on surgically induced endometriosis in rat models. Study design: Endometrial tissue was implanted onto the abdominal peritoneum of 26 rats that were randomized into 3 groups. The rats in group 1(n = 9) were subcutaneously administered with 0.02 mg/kg/d of octreotide (a short-acting analog) for 28 days. The rats in group 2 (n = 8) were subcutaneously injected with 20 mg/kg of a single dose of a long-acting analogue lanreotide The rats in group 3 were given no medication and served as controls (n = 9). Results: Mean volume and histologic score of implants in groups 1 (P < .01 and P < .05, respectively) and 2 (P < .01 and P < .05, respectively) were significantly lower than that in group 3. There were significant reductions in vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP-9) immunoreactivities in group 1 (0.67 +/- 0.50 and 1.22 +/- 0.44, respectively; both P < .01) and group 2 (0.71 +/- 0.48 and 0.86 +/- 0.69, respectively; both P < .01) when compared with the control group (1.78 +/- 0.83 and 2.11 +/- 0.78, respectively). Conclusion: Somatostatin analogs has regressed significantly the size of the endometriotic implants and caused atrophy of these lesions in rats by decreasing explant levels of VEGF and MMP-9.
dc.identifier10.1109/tbme.2009.2036598
dc.identifier.citationSevket O., SEVKET A., MOLLA T., Buyukpinarbasili N., Uysal O., YILMAZ B., DANE B., KELEKCI S., -Somatostatin Analogs Regress Endometriotic Implants in Rats by Decreasing Implant Levels of Vascular Endothelial Growth Factor and Matrix Metaloproteinase 9-, REPRODUCTIVE SCIENCES, cilt.20, ss.639-645, 2013
dc.identifier.pubmed23171679
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6696
dc.language.isoen
dc.titleSomatostatin Analogs Regress Endometriotic Implants in Rats by Decreasing Implant Levels of Vascular Endothelial Growth Factor and Matrix Metaloproteinase 9
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
local.avesis.ida6eeded0-ddc8-429e-b381-326b8ff79eeb
local.avesis.response6572
relation.isAuthorOfPublicationeb8392bc-16a3-4ddb-b3d1-08d16af341ec
relation.isAuthorOfPublication07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
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