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Upper airway tract and upper gastrointestinal tract involvement in patients with pemphigus vulgaris

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dc.contributor.authorSU, Ozlem
dc.contributor.authorOnsun, NAHİDE
dc.contributor.authorTeker, Aysenur Meric
dc.contributor.authorCINKAYA, Ayse
dc.contributor.authorKORKUT, Arzu Yasemin
dc.contributor.authorSEREMET, Sila
dc.contributor.authorDAVUTOGLU, Can
dc.contributor.authorDemirkesen, Cuyan
dc.contributor.institutionauthorSU KÜÇÜK, ÖZLEM
dc.contributor.institutionauthorONSUN, NAHIDE
dc.date.accessioned2019-10-05T13:45:50Z
dc.date.available2019-10-05T13:45:50Z
dc.date.issued2010-11-01
dc.description.abstractPemphigus vulgaris (PV) is an autoimmune disease involving the skin and mucous membranes. The frequency of upper airway tract (UAT) and upper gastrointestinal tract (UGIT) involvement in PV is not clearly known. Our aim was to determine the incidence of UAT and UGIT involvement in patients with PV. Thirty-seven patients who were diagnosed with PV and treated between March 2008 and April 2009 at the Dermatology Department of the Vakif Gureba Teaching and Research Hospital were included. All patients were evaluated for UAT manifestations by endoscopic examination, and 22 of 37 patients were investigated for UGIT involvement by gastrointestinal endoscopy. Mucosal biopsies were obtained by UGIT endoscopy for direct immunofluorescence (DIF) examination, and a histopathological examination was conducted in patients with active UGIT mucosal lesions. Thirty-five of 37 patients (94.6%) had active pharyngeal, laryngeal, or nasal PV lesions on endoscopic evaluation. Oral symptoms (83.8%) and active oral PV lesions were the most frequent findings (100%). Pharyngeal lesions (64.9%) were the most commonly present lesions on UAT examination. The frequency for laryngeal and nasal lesions was 51.4% and 21.6%, respectively. Five of 22 patients (22.7%) presented with active laryngeal and esophageal lesions. Twenty-one of 22 (95.4%) patients had positive DIF results. We believe that UAT and UGIT endoscopies are useful and necessary diagnostic methods in patients with PV with or without UAT and UGIT symptoms. UAT and UGIT endoscopies should be performed as standard diagnostic procedures in all patients with PV.
dc.identifier10.3906/sag-1509-101
dc.identifier.citationSU O., Onsun N., Teker A. M. , CINKAYA A., KORKUT A. Y. , SEREMET S., DAVUTOGLU C., Demirkesen C., -Upper airway tract and upper gastrointestinal tract involvement in patients with pemphigus vulgaris-, EUROPEAN JOURNAL OF DERMATOLOGY, cilt.20, ss.792-796, 2010
dc.identifier.doi10.1684/ejd.2010.1121
dc.identifier.scopus78649812363
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2932
dc.identifier.wosWOS:000284998000022
dc.language.isoen
dc.titleUpper airway tract and upper gastrointestinal tract involvement in patients with pemphigus vulgaris
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTURKISH JOURNAL OF MEDICAL SCIENCES
local.avesis.id472e6687-1b3b-4410-b5b3-fa1559031ac3
local.avesis.response2802
local.publication.isinternational1
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relation.isAuthorOfPublication1ebc9a95-ecf2-4c81-9f74-3c5fb32a9406
relation.isAuthorOfPublication.latestForDiscoveryfd8dc121-9bbe-4ee4-a2fd-5e237676169d
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