Publication:
NF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer

Simple item page
dc.contributor.authorEskandari, Zahra
dc.contributor.authorBAHADORİ, FATEMEH
dc.contributor.authorYapaoz, Melda Altkatoglu
dc.contributor.authorYenign, VİLDAN BETÜL
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorOnyuksel, Hayat
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorYENİGÜN, VILDAN BETÜL
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2019-12-13T20:59:05Z
dc.date.available2019-12-13T20:59:05Z
dc.date.issued2019-09-01
dc.description.abstractThis study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-kappa B) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2 -Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly (ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-kappa B levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-kappa B subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.
dc.identifier.citationEskandari Z., BAHADORİ F., Yapaoz M. A. , Yenign V. B. , KOÇYİĞİT A., Onyuksel H., -NF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer-, RECORDS OF NATURAL PRODUCTS, cilt.13, ss.390-404, 2019
dc.identifier.doi10.25135/rnp.108.18.10.984
dc.identifier.scopus85072061999
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10635
dc.identifier.wosWOS:000484075000004
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleNF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer
dc.typeArticle
dspace.entity.typePublication
local.avesis.id3c8dcb2c-f416-4a08-b9a4-b7fdbe3ec1cc
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublication9ec4f65d-c9aa-49eb-80ab-ce9ddce6bdba
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Collections
Yayınlar - Eserler