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The Correlation of Increased CRP Levels with NFKB1 and TLR2 Polymorphisms in the Case of Morbid Obesity

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dc.contributor.authorSoydas, T.
dc.contributor.authorKaraman, O.
dc.contributor.authorArkan, H.
dc.contributor.authorYenmis, G.
dc.contributor.authorILHAN, M. M.
dc.contributor.authorTombulturk, K.
dc.contributor.authorTASAN, ERTUĞRUL
dc.contributor.authorSultuybek, G. Kanigur
dc.contributor.institutionauthorKARAMAN, ÖZCAN
dc.contributor.institutionauthorİLHAN, MAHMUT MUZAFFER
dc.contributor.institutionauthorTAŞAN, ERTUĞRUL
dc.date.accessioned2019-10-05T14:27:14Z
dc.date.available2019-10-05T14:27:14Z
dc.date.issued2016-11-01
dc.description.abstractMorbid obesity (MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP). Toll-like receptor is possible candidate for inflammatory responses which is mainly mediated by NFKB1. The aim of this study was to investigate the relationship between NFKB1 and Toll-like receptor (TLR) 2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analysed the distribution of NFKB1-94 ins/del ATTG rs28362491 and TLR2 Arg753Gln rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls. The frequency of the ins/ins genotype and ins allele of rs28362491 was significantly higher in the patients compared to control group (P: 0.0309; P: 0.0421, respectively). Additionally, the frequency of GG genotype and G allele of rs5743708 was found to be statistically higher in the patient group (P: 0.0421; P < 0.0001, respectively). In addition, serum CRP levels (>20 mg/l) in MO patients with ins/ins genotype were significantly higher than in patients with del/ins genotype (P: 0.0309). Serum CRP levels were also higher in MO patients with GG genotype and G allele (P: 0.0001). According to combined analysis, the wild type of rs28362491 and rs5743708 polymorphisms (ins/ins/GG genotype) was also significantly higher in the patient group versus the control group when compared with the combined ins/ins/GA and del/ins/GA genotype (P < 0.0001). Therefore, our findings suggest that rs28362491 and rs5743708 polymorphisms were significantly associated with MO disease through acting by modulating serum CRP levels.en
dc.identifier10.1021/np9700681
dc.identifier.citationSoydas T., Karaman O., Arkan H., Yenmis G., ILHAN M. M. , Tombulturk K., TASAN E., Sultuybek G. K. , -The Correlation of Increased CRP Levels with NFKB1 and TLR2 Polymorphisms in the Case of Morbid Obesity-, SCANDINAVIAN JOURNAL OF IMMUNOLOGY, cilt.84, ss.278-283, 2016
dc.identifier.doi10.1111/sji.12471
dc.identifier.pubmed27507606
dc.identifier.scopus84992469959
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3928
dc.identifier.wosWOS:000387049300004
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe Correlation of Increased CRP Levels with NFKB1 and TLR2 Polymorphisms in the Case of Morbid Obesity
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF NATURAL PRODUCTS
local.avesis.id5f6d6f71-a820-4d67-9064-b69012d00b58
local.avesis.response3798
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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