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Amikacin induced renal damage and the role of the antioxidants on neonatal rats

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dc.contributor.authorKARA, ASLIHAN
dc.contributor.authorÇETİN, Hasan
dc.contributor.authorOktem, Faruk
dc.contributor.authorÇİRİŞ, İbrahim Metin
dc.contributor.authorAltuntas, Irfan
dc.contributor.authorKAYA, SELÇUK
dc.date.accessioned2020-10-29T22:22:30Z
dc.date.available2020-10-29T22:22:30Z
dc.date.issued2016-06-01T00:00:00Z
dc.description.abstractAmikacin (AK) is frequently used on the treatment of Gram-negative infections on neonates, but its usage is restricted because of nephrotoxicity. In this study, on neonatal rats, we aimed to investigate the effects of erythropoietin and vitamin E on AK induced nephrotoxicity. A total of 35 newborn Wistar Albino rats were divided into four groups: (1) injected with saline (serum physiological was administered to placebo controls), (2) injected with AK (1200mg/kg), (3) injected with AK+vitamin E (150mg/kg), (4) injected with AK+erythropoietin (EPO) (300IU/kg/day). In renal tissue, AK levels were significantly high in all groups except the control. Tissue malondialdehyde (MDA) and nitric oxide (NO) levels were statistically higher in AK -treated group than the control. MDA and NO levels were significantly decreased with the administration of vitamin E and EPO. Glutathione peroxidase (GPX) levels were statistically low in AK group compared with the controls. The levels of GPX, in vitamin E group, were increased significantly. However, superoxide dismutase and catalase levels were not significantly different in none of the groups. Insulin-like growth factor-1 values in AK, EPO and vitamin E groups were significantly higher than the control group. Histomorphological changes such as tubular epithelial necrosis were seen in AK treated group. Histopathological improvements observed with EPO and vitamin E administration. AK nephrotoxicity is related to oxidative stress and is supported with biochemical and histopathological findings. Vitamin E and EPO, as antioxidants, can be useful renoprotective agents for ameliorating AK induced nephrotoxicity in neonates.
dc.identifier.citationKARA A., ÇETİN H., Oktem F., ÇİRİŞ İ. M. , Altuntas I., KAYA S., -Amikacin induced renal damage and the role of the antioxidants on neonatal rats-, RENAL FAILURE, cilt.38, ss.671-677, 2016
dc.identifier.doi10.3109/0886022x.2016.1155393
dc.identifier.pubmed26982694
dc.identifier.scopus84961213844
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26577
dc.identifier.wosWOS:000378756000003
dc.titleAmikacin induced renal damage and the role of the antioxidants on neonatal rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaf15a2d8-afb0-4433-961b-022e1e38bcc9
local.publication.isinternational1
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