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Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats.

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dc.contributor.authorTugcu, BETÜL
dc.contributor.authorNACAROGLU, SA
dc.contributor.authorGEDIKBASI, A
dc.contributor.authorUHRI, M
dc.contributor.authorACAR, N
dc.contributor.authorÖZDEMIR, HÜSEYİN
dc.contributor.institutionauthorTUĞCU, BETÜL
dc.contributor.institutionauthorÖZDEMİR, MEHMET HAKAN
dc.date.accessioned2019-10-05T21:19:16Z
dc.date.available2019-10-05T21:19:16Z
dc.date.issued2017-11-18
dc.description.abstractAim: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. Methods: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ).The retina tissues were used to determine 8-hydroxy-2'-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Results: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P=0.001, P<0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P=0.004, P<0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P≤0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P=0.010, P=0.042, respectively) but SOD activity was not statistically different (P=0.938). Conclusion: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.en
dc.identifier10.1080/0972060x.2014.971060
dc.identifier.citationTugcu B., NACAROGLU S., GEDIKBASI A., UHRI M., ACAR N., ÖZDEMIR H., -Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats.-, International journal of ophthalmology, cilt.10, ss.1662-1668, 2017
dc.identifier.doi10.18240/ijo.2017.11.05
dc.identifier.pubmed29181308
dc.identifier.scopus85035197881
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7064
dc.identifier.wosWOS:000415603300005
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleProtective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF ESSENTIAL OIL BEARING PLANTS
local.avesis.idb0426a9a-ace1-4d56-867c-8456d7ebbda0
local.avesis.response6940
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication14827d60-5a60-4332-82d8-cfd0b8a19287
relation.isAuthorOfPublication9060b30f-7577-47e2-8bee-b2e001a19e7f
relation.isAuthorOfPublication.latestForDiscovery14827d60-5a60-4332-82d8-cfd0b8a19287
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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