Publication: Beta talasemi minörde serum ürotensin II düzeyi incelenmesi
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Date
2017
Authors
Authors
BURHAN, Şebnem
Journal Title
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Volume Title
Publisher
Bezmialem Vakıf University
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Abstract
Introduction and Purpose: Beta Thalassemia Minor (BTM) is a chronic hemolytic anemia
due to impaired hemoglobin structure due to poor production of beta globulin chain in
hemoglobin structure. Cerebrovascular and cardiovascular events in BTM have been shown in
studies performed less frequently. Mechanism has not been fully elucidated. Urotensin is the
most potent known vasoconstrictor. Studies have shown that Urotensin II is elevated in
essential hypertension, congestive heart failure, metabolic syndrome, and carotid artery
stenosis. We also thought that the possible low UII levels in BTM might be a minor effect of
cerebrovascular and cardiovascular pathologies in our study and we aimed to investigate
serum urotensin II level in BTM patients.
Material and Methods: The subjects included in the study were divided into two groups, the
BTM group (Group 1-n: 45) and the healthy controls (Group 2-n: 46). Comorbidities and drug
use that are known to affect the level of urotensin II and drug use have been identified as
exclusion criteria for the study. Urotensin II measurements were performed using ELISA kits.
Results: In the BTM group (Group 1), 46 people were included in the study group (Group 2).
There was no difference between the two groups in terms of gender, age, and BMI (p: 0.69, p:
0,166, p: 0,145). Plasma UII level averages were 352.65 ± 130.46 ng / L in Group 1 and
222.88 ± 80.44 ng / L in Group 2. Group 1 was statistically significantly higher (p <0.001).
UII levels were significantly correlated with HbA2 in the positive direction (p: <0.001, r:
0.482). There was no relationship between UII levels, age, sex, and BMI.
Conclusion: In our study, we had the opposite result of our hypothesis. We expected to find
the UII molecule low in Group 1. We think that high UII levels in the BTM group are highly
detected as hemolysis and anemia secondary to ineffective erythropoiesis in BTM. The
correlation of UII level with HbA2 supports this. We think that more comprehensive studies
on the effect of other protective factors should be made in less frequent ischemic vascular
pathologies in BTM.
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Description
Thesis (Medical)--Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, 2017
Keywords
Hematoloji = Hematology