Publication:
A Giant Ovarian Cyst in a Neonate with Classical 21-Hydroxylase Deficiency with Very High Testosterone Levels Demonstrating a High-Dose Hook Effect

Simple item page
dc.contributor.authorGÜRAN, TÜLAY
dc.contributor.authorYesil, GÖZDE
dc.contributor.authorGuran, Omer
dc.contributor.authorCesur, Suna
dc.contributor.authorBosnali, Oktav
dc.contributor.authorCelayir, Aysenur
dc.contributor.authorTopcuoglu, Sevilay
dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.institutionauthorYEŞİL, GÖZDE
dc.date.accessioned2020-10-29T22:48:37Z
dc.date.available2020-10-29T22:48:37Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractCongenital adrenal hyperplasia (CAH) is a group of disorders affecting the adrenal steroid synthesis. The most common form, 21-hydroxylase deficiency (21-OHD), leads to decreased production of cortisol and aldosterone with increased androgen secretion. In classic CAH, glucocorticoid treatment can be life-saving and serves to bring the symptoms under control. However, the treatment challenge is to effectively control the excess androgen effect by using the lowest possible glucocorticoid dose. Previous studies suggested a relationship between ovarian cyst formation and adrenal androgen excess, but neonatal large ovarian cysts have been very rarely reported in newborns with CAH. Here, we present the unique case of a neonate with classical 21-OHD who underwent surgery for a giant (10x8x7 cm) unilateral solitary ovarian follicular cyst on the 2nd postnatal day. Hormonal evaluation of the patient revealed high-dose hook effect for serum testosterone levels for the first time by a two-site immunoradiometric assay. Possible mechanisms by which androgen excess may cause ovarian cyst formation are discussed.
dc.identifier.citationGÜRAN T., Yesil G., Guran O., Cesur S., Bosnali O., Celayir A., Topcuoglu S., BEREKET A., -A Giant Ovarian Cyst in a Neonate with Classical 21-Hydroxylase Deficiency with Very High Testosterone Levels Demonstrating a High-Dose Hook Effect-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.4, ss.151-153, 2012
dc.identifier.doi10.4274/jcrpe.685
dc.identifier.scopus84866459221
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26752
dc.identifier.wosWOS:000209012700007
dc.titleA Giant Ovarian Cyst in a Neonate with Classical 21-Hydroxylase Deficiency with Very High Testosterone Levels Demonstrating a High-Dose Hook Effect
dc.typeArticle
dspace.entity.typePublication
local.avesis.idc257ca3c-a712-4815-9556-af6ba4d63629
local.publication.isinternational1
relation.isAuthorOfPublicationb653abbc-327a-4b3b-a227-f3344d8d6b70
relation.isAuthorOfPublication.latestForDiscoveryb653abbc-327a-4b3b-a227-f3344d8d6b70
Files
Collections
Silinecekler