Mean platelet volume as a diagnostic parameter of respiratory syncytial virus infection

Abstract

Our aim was to investigate RSV related parameters by comparing clinical findings and physical examination with routinely ordered whole blood counts and biochemical variables in under two age children hospitalized for lower respiratory tract infections. The sample consisted of 193 children [RSV positive (n=85), RSV negative (n=108)] with lower respiratory tract infections from May 2010 to May 2013. Sociodemographic findings, chief complaints and physical examination findings were retrospectively evaluated. RSV positive and negative groups were compared using Chi-square test (% 95 Confidence Interval- %95 CI), Mann-Whitney U test (p=0.05). No significant differences were found in demographic variables and treatment decisions between two groups. In RSV positive group, higher hyponatremia (p ≤0.001) and AST values (p=0.003) were found. Decreased MPV were determined 71.8% in RSV positive group. RSV positive patients had decreased MPV values (OR:10.929, 95% CI). Higher hyponatremia and increased AST values were found to be associated with RSV infection; and decreased MPV was significantly related with RSV infection. This is the second study in literature within our knowledge that found decreased MPV values in RSV positive patients. The mechanism related with decreased MPV, hyponatremia, and increased AST values in RSV infection should be investigated further.