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Endoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasite

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dc.contributor.authorKamil M.
dc.contributor.authorKINA Ü. Y.
dc.contributor.authorAtmaca H. N.
dc.contributor.authorUnal S.
dc.contributor.authorDeveci G.
dc.contributor.authorBurak P.
dc.contributor.authorAly A. S. I.
dc.contributor.institutionauthorKAMIL, MOHD
dc.contributor.institutionauthorKINA, ÜMİT YAŞAR
dc.contributor.institutionauthorDEVECİ, GÖZDE
dc.date.accessioned2024-02-12T21:50:56Z
dc.date.available2024-02-12T21:50:56Z
dc.date.issued2024-01-18
dc.description.abstractEndoplasmic reticulum (ER) plays a pivotal role in the regulation of stress responses in multiple eukaryotic cells. However, little is known about the effector mechanisms that regulate stress responses in ER of the malaria parasite. Herein, we aimed to identify the importance of a transmembrane protein 33 (TMEM33)-domain-containing protein in life cycle of the rodent malaria parasite Plasmodium berghei. TMEM33 is an ER membrane-resident protein that is involved in regulating stress responses in various eukaryotic cells. A C-terminal tagged TMEM33 was localized in the ER throughout the blood and mosquito stages of development. Targeted deletion of TMEM33 confirmed its importance for asexual blood stages and ookinete development, in addition to its essential role for sporozoite infectivity in the mammalian host. Pilot scale analysis shows that the loss of TMEM33 results in the initiation of ER stress response and induction of autophagy. Our findings conclude an important role of TMEM33 in the development of all life cycle stages of the malaria parasite, which indicates its potential as an antimalarial target.
dc.identifier.citationKamil M., KINA Ü. Y., Atmaca H. N., Unal S., Deveci G., Burak P., Aly A. S. I., "Endoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasite", MOLECULAR MICROBIOLOGY, 2024
dc.identifier.doi10.1111/mmi.15228
dc.identifier.issn0950-382X
dc.identifier.urihttps://avesis.bezmialem.edu.tr/api/publication/b590b5fd-2232-43b8-b1b6-144401a1784d/file
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39092
dc.identifier.wosWOS:001145087500001
dc.relation.ispartofMOLECULAR MICROBIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectMICROBIOLOGY
dc.subjectİlaç Keşfi
dc.subjectYapısal Biyoloji
dc.subjectMoleküler Biyoloji
dc.subjectKlinik Biyokimya
dc.subjectKanser Araştırmaları
dc.subjectBiyokimya
dc.subjectYaşlanma
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectDrug Discovery
dc.subjectStructural Biology
dc.subjectMolecular Biology
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectBiochemistry
dc.subjectAging
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.titleEndoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasite
dc.typearticle
dspace.entity.typePublication
local.avesis.idb590b5fd-2232-43b8-b1b6-144401a1784d
relation.isAuthorOfPublication90dbf8d7-063b-4fdc-9373-f3678809a1ea
relation.isAuthorOfPublicationc3765050-04eb-4a05-9f88-b9913d0f1f06
relation.isAuthorOfPublication08bb8616-7c86-4da4-b9fd-0944c55f8627
relation.isAuthorOfPublication.latestForDiscovery90dbf8d7-063b-4fdc-9373-f3678809a1ea
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