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LIMS1 Risk Genotype and T-Cell Mediated Rejection in Kidney Transplant Recipients.

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dc.contributor.authorÇalışkan, Yaşar
dc.contributor.authorKarahan, Gonca
dc.contributor.authorUsta Akgül, Sebahat
dc.contributor.authorMirioğlu, Şafak
dc.contributor.authorÖzlük, Mesude Yasemin
dc.contributor.authorYazıcı, Halil
dc.contributor.authorDemir, Erol
dc.contributor.authorDirim, Ahmet Burak
dc.contributor.authorTürkmen, Aydın
dc.contributor.authorEdwards, John
dc.contributor.authorOğuz Savran, Fatma
dc.contributor.authorSever, Mehmet Şükrü
dc.contributor.authorKiryluk, Krzysztof
dc.contributor.authorGharavi, Ali
dc.contributor.authorLentine, Krista L
dc.contributor.institutionauthorMİRİOĞLU, ŞAFAK
dc.date.accessioned2021-05-01T20:59:10Z
dc.date.available2021-05-01T20:59:10Z
dc.date.issued2021-04-28T00:00:00Z
dc.description.abstractBackground:This study aims to examine the association of LIM Zinc Finger Domain Containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort.Methods:We genotyped 841 kidney transplant recipients for LIMS1 rs893403 variant by Sanger sequencing followed by PCR confirmation of the deletion. Recipients who were homozygous for LIMS1 rs893403 genotype GG were compared to AA/AG genotypes. The primary outcome was T-cell mediated (TCMR) or antibody mediated rejection (ABMR) and secondary outcome was allograft loss.Results:After a median follow-up of 11.4 years, the rate of TCMR was higher in recipients with the GG (n = 200) compared to AA/AG (n = 641) genotypes [25 (12.5%) vs 35 (5.5%); p = 0.001] while ABMR did not differ by genotype [18 (9.0%) vs 62 (9.7%)]. Recipients with GG genotype had 2.4-times higher risk of TCMR than those who did not have this genotype (adjusted hazard ratio (aHR), 1.442.434.12, p = 0.001). A total of 189 (22.5%) recipients lost their allografts during follow up. Kaplan-Meier estimates of 5-year (94.3% vs. 94.4%, p = 0.99) and 10-year graft survival rates (86.9% vs. 83.4%, p = 0.31) did not differ significantly in those with GG compared to AA/AG groups.Conclusions:Our study demonstrates that recipient LIMS1 risk genotype is associated with increased risk of TCMR after kidney transplantation, confirming the role of LIMS1 locus in allograft rejection. These findings may have clinical implications for the prediction and clinical management of kidney transplant rejection by pretransplant genetic testing of recipients and donors for LIMS1 risk genotype.
dc.identifier.citationÇalışkan Y., Karahan G., Usta Akgül S., Mirioğlu Ş., Özlük M. Y. , Yazıcı H., Demir E., Dirim A. B. , Türkmen A., Edwards J., et al., -LIMS1 Risk Genotype and T-Cell Mediated Rejection in Kidney Transplant Recipients.-, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021
dc.identifier.doi10.1093/ndt/gfab168
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28822
dc.titleLIMS1 Risk Genotype and T-Cell Mediated Rejection in Kidney Transplant Recipients.
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida2734911-6f44-4c99-a243-9ceb4a0b4b2f
local.publication.isinternational1
relation.isAuthorOfPublication1a6fde04-64ba-4074-8a18-b696ffbbbd3e
relation.isAuthorOfPublication.latestForDiscovery1a6fde04-64ba-4074-8a18-b696ffbbbd3e
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