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Management of extravasation of oxaliplatin by mimicking its biotransformation

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dc.contributor.authorBahadori, F.
dc.contributor.authorDemiray, M.
dc.date.accessioned2020-10-22T18:54:47Z
dc.date.available2020-10-22T18:54:47Z
dc.date.issued2018-10-01T00:00:00Z
dc.description.abstractAlthough oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms of forming the DNA adducts. Thus, inhibiting transformation of di-chloro to di-aqua derivatives by accumulating chloride ions at the site of extravasation and saturating the Oxali molecule with these ions is a strategy that could help manage extravasation. Injecting normal saline at this site is a simple yet effective way to achieve this goal.
dc.identifier.citationBahadori F., Demiray M., -Management of extravasation of oxaliplatin by mimicking its biotransformation-, CLINICAL & TRANSLATIONAL ONCOLOGY, cilt.20, ss.1353-1357, 2018
dc.identifier.doi10.1007/s12094-018-1854-z
dc.identifier.pubmed29704231
dc.identifier.scopus85046035980
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24343
dc.identifier.wosWOS:000445074300015
dc.titleManagement of extravasation of oxaliplatin by mimicking its biotransformation
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida544b5b1-5194-49b0-bcaf-86dbc5819386
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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