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Photo-crosslinked mechanically strong PCL4-PDMAEM hydrogels

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dc.contributor.authorTuncaboylu, DENİZ CEYLAN
dc.contributor.institutionauthorTUNCABOYLU, DENIZ CEYLAN
dc.date.accessioned2019-10-05T21:28:49Z
dc.date.available2019-10-05T21:28:49Z
dc.date.issued2018-05-01
dc.description.abstractIn this study, a series of thermo-responsive hydrogels based on N-N-dimethylaminoethyl methacrylate (DMAEM) and methacrylate functionalized poly(caprolactone) (PCL4-IEMA) were prepared by bulk photo-polymerization method. Poly(caprolactone) (PCL) was modified with 2-isocyanatoethylmethacrylate (IEMA) to form a macrocrosslinker due to its excellent biocompatibility to generate high-strength smart hydrogels with pH and temperature responsivity. The synthesized macro-crosslinker and PCL4-PDMAEM hydrogel were characterized by H-1 NMR, GPC and FT-IR analyses. Sol-gel transitions were examined by oscillatory measurements in Rheometer under UV light. Swelling kinetics as a function of time, swelling ratios at different pH values and temperatures were studied. pH responsive swelling behavior of PCL4-PDMEAM hydrogels was demonstrated with a highest swelling value at pH = 2. Temperature responsivity was also proved with a LCST around 40 degrees C between the shrunken and swollen state. Young modulus of the sample was also calculated around 0.3 MPa. The results indicated that using PCL4-IEMA as a macro-crosslinker is an effective way to obtain mechanically strong - tough hydrogels by means of dissipating the applied energy through flexible crosslink units. In addition, swelling and mechanical properties of the hydrogels could be tailored by varying the amount of the crosslinker.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.5334/jbr-btr.59
dc.identifier.citationTuncaboylu D. C. , -Photo-crosslinked mechanically strong PCL4-PDMAEM hydrogels-, REACTIVE & FUNCTIONAL POLYMERS, cilt.126, ss.44-51, 2018
dc.identifier.doi10.1016/j.reactfunctpolym.2018.03.001
dc.identifier.scopus85044153906
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7402
dc.identifier.wosWOS:000436214500006
dc.language.isoen
dc.titlePhoto-crosslinked mechanically strong PCL4-PDMAEM hydrogels
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
local.avesis.idb860938d-d363-44bf-9f9e-5920c12127b8
local.avesis.response7278
local.publication.isinternational1
relation.isAuthorOfPublicationac53edd0-862b-4855-8c83-91c45c3cfd61
relation.isAuthorOfPublication.latestForDiscoveryac53edd0-862b-4855-8c83-91c45c3cfd61
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