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The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line

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dc.contributor.authorKaplan, Ayse
dc.contributor.authorBenkli, KADRİYE
dc.contributor.authorKoparal, Ayse Tansu
dc.contributor.institutionauthorBENKLİ, KADRIYE
dc.date.accessioned2019-10-05T21:22:43Z
dc.date.available2019-10-05T21:22:43Z
dc.date.issued2018-10-01
dc.description.abstractPurpose The aim of this study is to detect apoptotic and cytotoxic/antiproliferative effects of a ligand substance and its metal derivatives. The substances were investigated by using an h-ras oncogene transformed rat embryo fibroblast cell line (5RP7). Methods The cytotoxic influences of dipyrido[3,2-a:2,3-c]phenazine ligand, dipyrido[3,2-a:2,3-c] phenazine-platinum(II) complex ([Pt(dppz)Cl-2]) and dipyrido[3,2-a:2,3-c] phenazine-gold(III) complex ([Au(dppz)Cl-2]Cl) were determined with MTT (3[4,5-dimetiltiyazol2-yl]-2,5-difeniltetrazolyum bromid) assay on 5RP7 cells. Results Dipyrido[3,2-a:2,3-c] phenazine, dipyrido[3,2-a:2,3-c] phenazine-platinum(II) complex ([Pt(dppz)Cl-2]) and dipyrido[3,2-a:2,3-c] phenazine-gold(III) complexes ([Au(dppz)Cl-2]Cl) caused significant increase in cytotoxicity in a dose and time dependent manner. The effects of dipyridophenazine ligand (dppz) and its metal derivatives on apoptosis were monitorized using cytotoxic dose (10M) DAPI fluorescent staining. It was shown that dppz and its compounds induced apoptosis. Conclusions These findings show that dpzz and its complexes can be studied as novel alternative chemotherapeutics in cancer treatment.
dc.identifier10.1016/j.eurpolymj.2009.04.001
dc.identifier.citationKaplan A., Benkli K., Koparal A. T. , -The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line-, INVESTIGATIONAL NEW DRUGS, cilt.36, ss.755-762, 2018
dc.identifier.pubmed29313280
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7151
dc.language.isoen
dc.titleThe in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameEUROPEAN POLYMER JOURNAL
local.avesis.idb24a81fd-7500-471c-a29d-fd80804a293f
local.avesis.response7027
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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relation.isAuthorOfPublication.latestForDiscovery7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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