Publication:
Short-term levosimendan treatment protects rat testes against oxidative stress

dc.contributor.authorYuksel, M. B.
dc.contributor.authorKavak, S.
dc.contributor.authorGecit, I.
dc.contributor.authorBasel, H.
dc.contributor.authorGumrukcuoglu, H. A.
dc.contributor.authorDemir, Halit
dc.contributor.authorMeral, I.
dc.contributor.institutionauthorMERAL, İSMAİL
dc.date.accessioned2020-10-29T14:44:10Z
dc.date.available2020-10-29T14:44:10Z
dc.date.issued2012-08-01T00:00:00Z
dc.description.abstractThe objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 mu g/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes.
dc.identifier.citationYuksel M. B. , Kavak S., Gecit I., Basel H., Gumrukcuoglu H. A. , Demir H., Meral I., -Short-term levosimendan treatment protects rat testes against oxidative stress-, BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, cilt.45, ss.716-720, 2012
dc.identifier.doi10.1590/s0100-879x2012007500075
dc.identifier.scopus84864650451
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25413
dc.identifier.wosWOS:000307713400005
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleShort-term levosimendan treatment protects rat testes against oxidative stress
dc.typeArticle
dspace.entity.typePublication
local.avesis.id2b08c12e-0eab-4f38-ae6d-1313ff465636
local.indexed.atWOS
local.indexed.atScopus
local.publication.isinternational1
relation.isAuthorOfPublication58058ee9-1440-480c-9817-c6b25d7ec008
relation.isAuthorOfPublication.latestForDiscovery58058ee9-1440-480c-9817-c6b25d7ec008

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