Publication: Short-term levosimendan treatment protects rat testes against oxidative stress
dc.contributor.author | Yuksel, M. B. | |
dc.contributor.author | Kavak, S. | |
dc.contributor.author | Gecit, I. | |
dc.contributor.author | Basel, H. | |
dc.contributor.author | Gumrukcuoglu, H. A. | |
dc.contributor.author | Demir, Halit | |
dc.contributor.author | Meral, I. | |
dc.contributor.institutionauthor | MERAL, İSMAİL | |
dc.date.accessioned | 2020-10-29T14:44:10Z | |
dc.date.available | 2020-10-29T14:44:10Z | |
dc.date.issued | 2012-08-01T00:00:00Z | |
dc.description.abstract | The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 mu g/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes. | |
dc.identifier.citation | Yuksel M. B. , Kavak S., Gecit I., Basel H., Gumrukcuoglu H. A. , Demir H., Meral I., -Short-term levosimendan treatment protects rat testes against oxidative stress-, BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, cilt.45, ss.716-720, 2012 | |
dc.identifier.doi | 10.1590/s0100-879x2012007500075 | |
dc.identifier.scopus | 84864650451 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/25413 | |
dc.identifier.wos | WOS:000307713400005 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Short-term levosimendan treatment protects rat testes against oxidative stress | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | 2b08c12e-0eab-4f38-ae6d-1313ff465636 | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 58058ee9-1440-480c-9817-c6b25d7ec008 | |
relation.isAuthorOfPublication.latestForDiscovery | 58058ee9-1440-480c-9817-c6b25d7ec008 |