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Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy

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dc.contributor.authorÖZKAN, FEYZA ÜNLÜ
dc.contributor.authorUZER, GÖKÇER
dc.contributor.authorTÜRKMEN, İSMAİL
dc.contributor.authorYILDIZ, YAVUZ
dc.contributor.authorŞENOL, SERKAN
dc.contributor.authorÖZKAN, KORHAN
dc.contributor.authorTÜRKMENSOY, FATİH
dc.contributor.authorRAMADAN, SAİME
dc.contributor.authorAKTAŞ, İLKNUR
dc.contributor.institutionauthorUZER, GÖKÇER
dc.date.accessioned2020-10-29T22:51:11Z
dc.date.available2020-10-29T22:51:11Z
dc.date.issued2015-01-01T00:00:00Z
dc.description.abstractObjective: The aim of this experimental study was to evaluate and compare the chondroprotective efficacy of intra-articular hyaluronic acid, tenoxicam and vitamin E in osteoarthritis. Methods: An osteoarthritis model was created by anterior cruciate ligament transection and medial menisectomy in knees of 28 rats. The rats were randomized into four groups; first group served as a control group and received intra-articular injections of saline solution, intra-articular HA, intra-articular tenoxicam and intra-articular Vit E were applied to the treatment groups. First intra-articular injections were applied at second week postoperatively and repeated once a week for 5 weeks. At 8th week after the operation groups were compared based on the histologic scores of cartilage degeneration by Mankin Histological Grading Scale. Results: Total cartilage degeneration score was significantly increased in the control group (P=0.004). Total Mankin scores of HA, tenoxicam and Vit E groups were significantly lower than the control group (P=0.004, P=0.016, P=0.012 respectively). There was no statistically siginificant difference between the treatment groups in terms of total Mankin scores (P>0.05). Conclusion: Intra-articular application of HA, tenoxicam and Vit E are chondroprotective in early osteoarthritis model in rats. Chondroprotective activity of tenoxicam and Vit E are comparable with the beneficial effects of HA on articular cartilage.
dc.identifier.citationÖZKAN F. Ü. , UZER G., TÜRKMEN İ., YILDIZ Y., ŞENOL S., ÖZKAN K., TÜRKMENSOY F., RAMADAN S., AKTAŞ İ., -Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.8, ss.1018-1026, 2015
dc.identifier.pubmed25785088
dc.identifier.scopus84922960155
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26774
dc.identifier.wosWOS:000349897200121
dc.titleIntra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy
dc.typeArticle
dspace.entity.typePublication
local.avesis.idc45efff4-30ac-4bab-86e6-18c621074758
local.publication.isinternational1
relation.isAuthorOfPublication2ac6eb83-fe07-4a95-8352-af58807d1d60
relation.isAuthorOfPublication.latestForDiscovery2ac6eb83-fe07-4a95-8352-af58807d1d60
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