Publication: Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy
dc.contributor.author | ÖZKAN, FEYZA ÜNLÜ | |
dc.contributor.author | UZER, GÖKÇER | |
dc.contributor.author | TÜRKMEN, İSMAİL | |
dc.contributor.author | YILDIZ, YAVUZ | |
dc.contributor.author | ŞENOL, SERKAN | |
dc.contributor.author | ÖZKAN, KORHAN | |
dc.contributor.author | TÜRKMENSOY, FATİH | |
dc.contributor.author | RAMADAN, SAİME | |
dc.contributor.author | AKTAŞ, İLKNUR | |
dc.contributor.institutionauthor | UZER, GÖKÇER | |
dc.date.accessioned | 2020-10-29T22:51:11Z | |
dc.date.available | 2020-10-29T22:51:11Z | |
dc.date.issued | 2015-01-01T00:00:00Z | |
dc.description.abstract | Objective: The aim of this experimental study was to evaluate and compare the chondroprotective efficacy of intra-articular hyaluronic acid, tenoxicam and vitamin E in osteoarthritis. Methods: An osteoarthritis model was created by anterior cruciate ligament transection and medial menisectomy in knees of 28 rats. The rats were randomized into four groups; first group served as a control group and received intra-articular injections of saline solution, intra-articular HA, intra-articular tenoxicam and intra-articular Vit E were applied to the treatment groups. First intra-articular injections were applied at second week postoperatively and repeated once a week for 5 weeks. At 8th week after the operation groups were compared based on the histologic scores of cartilage degeneration by Mankin Histological Grading Scale. Results: Total cartilage degeneration score was significantly increased in the control group (P=0.004). Total Mankin scores of HA, tenoxicam and Vit E groups were significantly lower than the control group (P=0.004, P=0.016, P=0.012 respectively). There was no statistically siginificant difference between the treatment groups in terms of total Mankin scores (P>0.05). Conclusion: Intra-articular application of HA, tenoxicam and Vit E are chondroprotective in early osteoarthritis model in rats. Chondroprotective activity of tenoxicam and Vit E are comparable with the beneficial effects of HA on articular cartilage. | |
dc.identifier.citation | ÖZKAN F. Ü. , UZER G., TÜRKMEN İ., YILDIZ Y., ŞENOL S., ÖZKAN K., TÜRKMENSOY F., RAMADAN S., AKTAŞ İ., -Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.8, ss.1018-1026, 2015 | |
dc.identifier.pubmed | 25785088 | |
dc.identifier.scopus | 84922960155 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/26774 | |
dc.identifier.wos | WOS:000349897200121 | |
dc.title | Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | c45efff4-30ac-4bab-86e6-18c621074758 | |
local.indexed.at | PubMed | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 2ac6eb83-fe07-4a95-8352-af58807d1d60 | |
relation.isAuthorOfPublication.latestForDiscovery | 2ac6eb83-fe07-4a95-8352-af58807d1d60 |