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Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats

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dc.contributor.authorKumas, MELTEM
dc.contributor.authorEsrefoglu, MUKADDES
dc.contributor.authorBayindir, NİHAN
dc.contributor.authorIraz, Meryem
dc.contributor.authorAyhan, Siddika
dc.contributor.authorMeydan, SEDAT
dc.contributor.institutionauthorKUMAŞ, MELTEM
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorBAYINDIR, NİHAN
dc.contributor.institutionauthorMEYDAN, SEDAT
dc.date.accessioned2019-10-05T14:13:36Z
dc.date.available2019-10-05T14:13:36Z
dc.date.issued2016-12-01
dc.description.abstractObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.3109/00365548.2014.926021
dc.identifier.citationKumas M., Esrefoglu M., Bayindir N., Iraz M., Ayhan S., Meydan S., -Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats-, BEZMIALEM SCIENCE, cilt.4, ss.92-98, 2016
dc.identifier.doi10.14235/bs.2016.788
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3292
dc.identifier.wosWOS:000390866000003
dc.language.isoen
dc.subjectCadmium
dc.titleProtective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
local.avesis.id5002491f-23d5-43a5-a718-b9b0c712bd3b
local.avesis.response3162
local.publication.isinternational1
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relation.isAuthorOfPublicationd0c7c343-3b7d-47ef-a2a7-5169234110eb
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relation.isAuthorOfPublication911e6cc8-a491-428f-b583-ec1b86181c34
relation.isAuthorOfPublication.latestForDiscovery3c2743d0-b951-4eb5-bdd8-1c932e717700
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