Publication:
A low direct electrical signal attenuates oxidative stress and inflammation in septic rats

Simple item page
dc.contributor.authorÜstünova, Savaş
dc.contributor.authorHacıosmanoğlu, Ebru
dc.contributor.authorBulut, Huri
dc.contributor.authorKılıç, Aysu
dc.contributor.authorHekimoğlu, Emine Rümeysa
dc.contributor.authorTunc, Serkan
dc.contributor.authorKaygusuz, İrem
dc.contributor.authorTunc, Sevil
dc.contributor.authorTunc, Gulcin Beyza
dc.contributor.authorMeral, Ismail
dc.contributor.institutionauthorÜSTÜNOVA, SAVAŞ
dc.contributor.institutionauthorHACIOSMANOĞLU, EBRU
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorKILIÇ, AYSU
dc.contributor.institutionauthorHEKİMOĞLU, EMİNE RÜMEYSA
dc.contributor.institutionauthorMERAL, İSMAİL
dc.date.accessioned2021-09-10T20:59:07Z
dc.date.available2021-09-10T20:59:07Z
dc.date.issued2021-09-01T00:00:00Z
dc.description.abstractElectrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.
dc.identifier.doi10.1371/journal.pone.0257177
dc.identifier.pubmed34499695
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29431
dc.subjectseptic rats
dc.subjectinflammation
dc.subjectelectrical signal
dc.titleA low direct electrical signal attenuates oxidative stress and inflammation in septic rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id5d3c412a-b120-4a4f-9c5b-0f5d44c149fe
local.publication.isinternational1
relation.isAuthorOfPublicationbebec550-3712-466a-8e2d-8f90006e62f6
relation.isAuthorOfPublicationfffb1a2f-62c4-40ee-8fc4-f0f3e62523b9
relation.isAuthorOfPublication1b1887fb-6b32-44b1-9d9f-416616dc6734
relation.isAuthorOfPublicationcac708f1-3a64-4312-b507-ad94d4212f60
relation.isAuthorOfPublication47739f84-bd54-4c7c-9a22-f2d415732282
relation.isAuthorOfPublication58058ee9-1440-480c-9817-c6b25d7ec008
relation.isAuthorOfPublication.latestForDiscovery58058ee9-1440-480c-9817-c6b25d7ec008
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.pdf
Size:
4.16 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler