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The role of plasma exchange in acute liver failure of autoimmune etiology

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dc.contributor.authorGokce, Selim
dc.contributor.authorCermik, Banu Bal
dc.contributor.authorKUTLU, NURETTİN ONUR
dc.contributor.authorOcak, Ilhan
dc.contributor.institutionauthorKUTLU, NURETTİN ONUR
dc.date.accessioned2021-06-01T20:59:09Z
dc.date.available2021-06-01T20:59:09Z
dc.date.issued2021-03-01T00:00:00Z
dc.description.abstractBackground: Autoimmune hepatitis (AIH) is characterized by increased immunoglobulin G (IgG) levels, the presence of autoantibodies, and various degrees of lymphocyte predominant inflammation and fibrosis histologically. Immunosuppressive therapy induces remission in approximately 80% of those affected. However, liver transplantation is indicated in patients with acute liver failure with encephalopathy at presentation. Liver supporting systems, including plasma exchange (PE) allow bridging patients to transplantation or spontaneous recovery in the setting of liver failure. The role of these systems has not been assessed in children with liver failure of autoimmune etiology. Case: Herein, we report three cases of AIH with fulminant presentation, with marked symptom resolution with PE as an adjunct therapeutic option to immunosuppressive treatment. Conclusion: In the setting of AIH, PE may have a special therapeutic role by removing autoantibodies and cytokines, therefore preventing further liver damage and decompensation, and allowing time for recovery.
dc.identifier.doi10.24953/turkjped.2021.02.019
dc.identifier.pubmed33929125
dc.identifier.scopus85105218059
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28939
dc.identifier.wosWOS:000646179400019
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchildren
dc.subjectplasma exchange
dc.subjecttreatment
dc.subjectautoimmune hepatitis
dc.titleThe role of plasma exchange in acute liver failure of autoimmune etiology
dc.typeArticle
dspace.entity.typePublication
local.avesis.idb2f06dd3-4ecd-4ba0-9251-14f98f25bf98
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery60f04671-ed09-4a15-b380-0c29cc668f39
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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