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A Liquid Chromatographic Analysis of Deferasirox in Human Breast Milk with Fluorimetric Detection

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dc.contributor.authorOnal, Cem
dc.contributor.authorASRAM SAĞIROĞLU, ALİ
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.contributor.institutionauthorASRAM SAĞIROĞLU, ALİ
dc.date.accessioned2020-10-22T16:01:27Z
dc.date.available2020-10-22T16:01:27Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractTo determine deferasirox in human breast milk a novel, sensitive high-performance liquid chromatographic method with fluorescence detection has been developed. Precolumn derivatization process is applied to achieve fluorescent analyte using 4-bromomethyl-7-methoxy coumarin (BrMmC) as a reagent and dibenzo-18-crown-6-ether as catalyst. The method depends on reverse phase chromatography. C(18)column has been used with 150 x 4.6 mm, 5 mu m particle size and the mobile phase consisting of acetonitrile:phosphate buffer (20 mM, pH 3) (70:30,v/v) with a flow rate of 1.0 mL/min. Fluorescence detection at 390 nm is provided with an excitation at 320 nm The linear range is 0.01-1.0 mu g/mL. The mean recovery has been calculated as 100.7% with a relative standard deviation (RSD) value less than 2%. The developed method was successfully applied for the determination of deferasirox in human breast milk samples.
dc.identifier.citationOnal C., TEKKELİ Ş. E. , ASRAM SAĞIROĞLU A., -A Liquid Chromatographic Analysis of Deferasirox in Human Breast Milk with Fluorimetric Detection-, CHROMATOGRAPHIA, 2020
dc.identifier.doi10.1007/s10337-020-03953-5
dc.identifier.scopus85090498154
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23863
dc.identifier.wosWOS:000568232100001
dc.titleA Liquid Chromatographic Analysis of Deferasirox in Human Breast Milk with Fluorimetric Detection
dc.typeArticle
dspace.entity.typePublication
local.avesis.id65917669-06d7-4916-b99e-0910e03ae1aa
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication8d4d976d-a790-465b-8db9-1707530c0551
relation.isAuthorOfPublication.latestForDiscovery837d5047-762e-43db-b252-9f3d1399378f
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