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Is pentraxin-3 stronger than C-reactive protein to determine inflammation in peritoneal dialysis patients?

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dc.contributor.authorGursu, MELTEM
dc.contributor.authorOZTURK, S.
dc.contributor.authorAYDIN, Z.
dc.contributor.authorKARADAG, S.
dc.contributor.authorDOVENTAS, Y.
dc.contributor.authorKOLDAS, M.
dc.contributor.authorUZUN, S.
dc.contributor.authorSUMNU, A.
dc.contributor.authorKAZANCIOĞLU, RÜMEYZA
dc.contributor.institutionauthorGÜRSU, MELTEM
dc.contributor.institutionauthorKAZANCIOĞLU, RÜMEYZA
dc.date.accessioned2019-10-05T15:16:29Z
dc.date.available2019-10-05T15:16:29Z
dc.date.issued2012-01-01
dc.description.abstractPentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7 +/- 12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16 +/- 2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.
dc.identifier
dc.identifier.citationGursu M., OZTURK S., AYDIN Z., KARADAG S., DOVENTAS Y., KOLDAS M., UZUN S., SUMNU A., KAZANCIOĞLU R., -Is pentraxin-3 stronger than C-reactive protein to determine inflammation in peritoneal dialysis patients?-, European Journal of Inflammation, cilt.10, ss.289-295, 2012
dc.identifier.doi10.1177/1721727x1201000305
dc.identifier.scopus84873417946
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5871
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/1721727X1201000305?icid=int.sj-abstract.similar-articles.2
dc.identifier.wosWOS:000313668100005
dc.language.isoen
dc.subjectdialysis
dc.titleIs pentraxin-3 stronger than C-reactive protein to determine inflammation in peritoneal dialysis patients?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameVAN TIP DERGİSİ
local.avesis.id9172afe5-2f29-463c-b797-6012d9e9a628
local.avesis.response5741
local.publication.isinternational1
relation.isAuthorOfPublicationa6446eac-0ccd-4457-9227-3fc72dec68d1
relation.isAuthorOfPublicationeca7bd30-6b6e-444d-96ae-2961c39f2107
relation.isAuthorOfPublication.latestForDiscoverya6446eac-0ccd-4457-9227-3fc72dec68d1
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