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All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats

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dc.contributor.authorYucel, Cem
dc.contributor.authorYucel, Elcin Erdogan
dc.contributor.authorArslan, Fatma Demet
dc.contributor.authorEkmekci, Sumeyye
dc.contributor.authorKisa, Erdem
dc.contributor.authorUlker, Volkan
dc.contributor.authorUcar, Murat
dc.contributor.authorIlbey, YUSUF ÖZLEM
dc.contributor.authorCelik, Orcun
dc.contributor.authorBasok, Banu Isbilen
dc.contributor.authorKozacioglu, Zafer
dc.contributor.institutionauthorİLBEY, YUSUF ÖZLEM
dc.date.accessioned2022-01-27T21:00:24Z
dc.date.available2022-01-27T21:00:24Z
dc.date.issued2019-02-01T00:00:00Z
dc.description.abstractThe aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1ml/kg saline intra-peritoneally (IP) during 10days. The rats in the ATRA group were injected a single dose of ATRA during 10days. The rats in the ATRA+CP group were injected a single dose of CP on the fourth day of the 10days of ATRA treatment. The rats in the CP group were injected a single dose of CP on the fourth day of 10days without administering a treatment. After treatment, the groups were compared with regard to total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels in renal tissue and renal histopathology. The serum creatinine and urea values were statistically significantly higher in the CP group compared to the other groups. The serum creatinine and urea values were statistically significantly lower in the ATRA+CP group when compared to the CP group. Although the TOS and OSI levels were found to be lower in the ATRA+CP group compared to the CP group, the difference was not statistically significant. Administration of ATRA together with CP was observed to reduce the histopathologic destruction in the kidney and lead to mild tubular degeneration, vacuolization, and necrosis (57.1% grade 1; 28.6% grade2, and 14.3% grade 3 necrosis). The results of the present study have revealed that ATRA administration ameliorates CP-induced nephrotoxicity; however, further studies are required to identify this issue before clinical application.
dc.identifier.citationYucel C., Yucel E. E. , Arslan F. D. , Ekmekci S., Kisa E., Ulker V., Ucar M., Ilbey Y. Ö. , Celik O., Basok B. I. , et al., -All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats-, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.392, sa.2, ss.159-164, 2019
dc.identifier.doi10.1007/s00210-018-01603-0
dc.identifier.scopus85059630791
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30344
dc.identifier.wosWOS:000457408700004
dc.titleAll-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.idded8f72b-f3e1-4fc9-bdf9-037c56893995
local.publication.isinternational1
relation.isAuthorOfPublicatione166fdca-de94-48b0-a771-14053e70c6ca
relation.isAuthorOfPublication.latestForDiscoverye166fdca-de94-48b0-a771-14053e70c6ca
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