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S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer

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dc.contributor.authorDESTEK, SABAHATTİN
dc.contributor.authorGul, Vahit Onur
dc.contributor.institutionauthorDESTEK, SABAHATTİN
dc.date.accessioned2020-10-22T15:56:42Z
dc.date.available2020-10-22T15:56:42Z
dc.date.issued2018-01-01T00:00:00Z
dc.description.abstractBackground. Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Methods. Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4. The protein expression levels of S100A4 in tumor tissue werematched with the clinicopathologic factors including patient survival. Results. Cytoplasmic expression of S100A4 protein was demonstrated in the tumor tissue of 132 patients (89.2%) out of a total of 148 study patients. Statistically, the expression levels of the cytoplasmic S100A4 protein correlated significantly with the TNM stages and patient survival. The distribution of the S100A4 protein staining in the tumor tissue was associated with the age groups, tumor localization, TNMstaging, and patient survival with statistical significance. The levels of S100A4 protein expressionwere found to be an independent prognostic factor for TNM staging and poor survival. Conclusion. Expression of the S100A4 protein in colon cancers may be an indicator of tumor progression and lymph node metastasis and may be useful for predicting the overall survival of the patients with colon cancer. In patients with colon cancer, it may be used as an indicator of poor prognosis.
dc.identifier.citationDESTEK S., Gul V. O. , -S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer-, JOURNAL OF ONCOLOGY, 2018
dc.identifier.doi10.1155/2018/1828791
dc.identifier.pubmed30111999
dc.identifier.scopus85050857615
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23702
dc.identifier.wosWOS:000439993800001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleS100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer
dc.typeArticle
dspace.entity.typePublication
local.avesis.id514ad6c8-27b1-463d-9d0d-007fc7316cbc
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication6510863e-f993-4bd8-af2c-8597f426b0e1
relation.isAuthorOfPublication.latestForDiscovery6510863e-f993-4bd8-af2c-8597f426b0e1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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