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An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats

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dc.contributor.authorTUGRUL, Selahattin
dc.contributor.authorDogan, REMZİ
dc.contributor.authorAKSOY, Fadlullah
dc.contributor.authorVEYSELLER, Bayrann
dc.contributor.authorOzer, Omer Faruk
dc.contributor.authorPEKTAS, Alev
dc.contributor.institutionauthorAKSOY, FADLULLAH
dc.contributor.institutionauthorDOĞAN, REMZI
dc.contributor.institutionauthorÖZTURAN, ORHAN
dc.contributor.institutionauthorTUĞRUL, SELAHATTİN
dc.contributor.institutionauthorÖZER, ÖMER FARUK
dc.date.accessioned2019-10-05T12:37:44Z
dc.date.available2019-10-05T12:37:44Z
dc.date.issued2015-12-01
dc.description.abstractObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.en
dc.identifier10.1007/s00775-019-01688-9
dc.identifier.citationAKSOY F., Dogan R., Ozturan O., TUGRUL S., VEYSELLER B., Ozer O. F. , PEKTAS A., -An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats-, CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.8, ss.312-319, 2015
dc.identifier.doi10.3342/ceo.2015.8.4.312
dc.identifier.pubmed26622947
dc.identifier.scopus84948161755
dc.identifier.urihttps://hdl.handle.net/20.500.12645/209
dc.identifier.wosWOS:000367117700002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAn Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of Biological Inorganic Chemistry
local.avesis.id01be2cd2-a24a-43a4-bbc3-aacd3d03395b
local.avesis.response
local.org.facultyTıp Fakültesi
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery24246249-6961-4f71-8382-1bf0f01b3c78
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