Publication:
Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients

dc.contributor.authorGOZUKARA, Mehmet Yavuz
dc.contributor.authorBorekci, Abdurrezzak
dc.contributor.authorGur, Mustafa
dc.contributor.authorAksoy, Nurten
dc.contributor.authorSEKER, Taner
dc.contributor.authorKAYPAKLI, Onur
dc.contributor.authorUCAR, Hakan
dc.contributor.authorTURKOGLU, Caner
dc.contributor.authorKOC, Mevlut
dc.contributor.authorMAKCA, Ilyas
dc.contributor.authorAKYOL, Selahattin
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorCAYLI, Murat
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.date.accessioned2019-10-05T23:14:19Z
dc.date.available2019-10-05T23:14:19Z
dc.date.issued2015-09-01
dc.description.abstractBackground: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Methods: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. Results: PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = -0.343, P < 0.001) as well as hs-CRP (β = 0.334, P < 0.001). Conclusion: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.en
dc.identifier
dc.identifier.citationGOZUKARA M. Y. , Borekci A., Gur M., Aksoy N., SEKER T., KAYPAKLI O., UCAR H., TURKOGLU C., KOC M., MAKCA I., et al., -Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients-, JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.29, ss.390-396, 2015
dc.identifier.doi10.1002/jcla.21785
dc.identifier.pubmed25131701
dc.identifier.scopus84941803305
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9780
dc.identifier.wosWOS:000363875800010
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleGamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTürkiye Klinikleri J Fam Med-Special Topics
local.avesis.idf3a22d17-79c7-4608-ab2e-a02e5dd42d2c
local.avesis.response9654
local.publication.isinternational1
relation.isAuthorOfPublication8eb7d539-8ea4-435c-830e-8ef630342c7d
relation.isAuthorOfPublication.latestForDiscovery8eb7d539-8ea4-435c-830e-8ef630342c7d
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