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Mallory-Denk Bodies in chronic hepatitis

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dc.contributor.authorBasaranoglu, METİN
dc.contributor.authorTURHAN, Nesrin
dc.contributor.authorSonsuz, Abdullah
dc.contributor.authorBasaranoglu, GÖKÇEN
dc.contributor.institutionauthorBAŞARANOĞLU, METİN
dc.contributor.institutionauthorBAŞARANOĞLU, GÖKÇEN
dc.date.accessioned2019-10-05T14:23:10Z
dc.date.available2019-10-05T14:23:10Z
dc.date.issued2011-05-07
dc.description.abstractMallory-Denk Bodies (MDB) are important as investigators, suggesting MDB as an indicator of the histologic severity of chronic hepatitis, causes of which include hepatitis C, primary biliary cirrhosis (PBC), and nonalcoholic fatty liver disease (NAFLD). Matteoni et al scored MDB in patients with NAFLD as none, rare and many, and reported that MDB plays a prominent role in this classification scheme in an earlier classification system. In this study, we evaluated 258 patients with chronic hepatitis due to metabolic, autoimmune and viral etiologies. Liver biopsy samples were evaluated with hematoxylin and eosin, periodic acid-Schiff-diastase, Gordon and Sweet-s reticulin, Masson-s trichrome, and iron stains. Both staging and grading were performed. Additionally, MDB were evaluated and discussed for each disease. We examined patients with nonalcoholic steatohepatitis (NASH; 50 patients), alcoholic hepatitis (10 patients), PBC (50 patients), Wilson disease (WD; 20 patients), hepatitis B (50 patients), hepatitis C (50 patients) and hepatocellular carcinoma (HCC; 30 patients). Frequency of MDB was as follows; NASH: 10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone 3. PBC: 11 patients with mild in 10%, moderate in 70%, and cirrhosis in 20%, and frequently seen in zone 1. WD: 16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone 1. Hep B: 3 patients with mild in 66% and severe in 34%. Hep C: 7 patients with mild in 40% and moderate in 60% and observed in every stage. HCC: 3 patients with hep B in 2 patients. We found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology. (C) 2011 Baishideng. All rights reserved.
dc.identifier10.1016/j.jmbbm.2013.09.016
dc.identifier.citationBasaranoglu M., TURHAN N., Sonsuz A., Basaranoglu G., -Mallory-Denk Bodies in chronic hepatitis-, WORLD JOURNAL OF GASTROENTEROLOGY, cilt.17, ss.2172-2177, 2011
dc.identifier.doi10.3748/wjg.v17.i17.2172
dc.identifier.pubmed
dc.identifier.scopus79955834598
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3734
dc.identifier.wosWOS:000290689300002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchronic hepatitis
dc.titleMallory-Denk Bodies in chronic hepatitis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
local.avesis.id5a8405e3-6b7b-4404-a50f-1af12e13c9fc
local.avesis.response3604
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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