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Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study

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dc.contributor.authorKIBAR, Ayse Esin
dc.contributor.authorUNVER, Olcay
dc.contributor.authorOFLAZ, MEHMET BURHAN
dc.contributor.authorGÜVEN, AHMET SAMİ
dc.contributor.authorBALLI, Sevket
dc.contributor.authorEce, Ibrahim
dc.contributor.authorERDEM, Sevcan
dc.contributor.authorİÇAĞASIOĞLU, FÜSUN DİLARA
dc.contributor.institutionauthorİÇAĞASIOĞLU, DİLARA FÜSUN
dc.date.accessioned2020-10-30T00:01:32Z
dc.date.available2020-10-30T00:01:32Z
dc.date.issued2014-02-01T00:00:00Z
dc.description.abstractImpaired cardiac myocardial function may contribute to the risk for sudden unexpected death of a patient with epilepsy. This study aimed to investigate the effect of antiepilepsy drugs (AEDs) on cardiac function in pediatric epileptic patients using standard and tissue Doppler imaging (TDI) echocardiography. This hospital-based, prospective cross-sectional study investigated 52 epileptic children (mean age 9.3 +/- A 3.1 years) treated with AEDs (duration 2.4-10.0 years) and 36 healthy children (mean age 9.5 +/- A 4.0 years). In the epilepsy group, standard echocardiography showed increased left ventricular (LV) end-diastolic and end-systolic diameters, an increased LV mass index, and preserved ejection fraction. The patients also exhibited increased mitral peak A-wave velocity and mitral E-wave deceleration time as well as a decreased mitral E/A ratio. The E/Em ratio was significantly higher in the epilepsy group (5.6 +/- A 1.2) than in the control group (5.2 +/- A 1.1) (p = 0.016). In the epilepsy group, TDI showed an increased isovolumetric relaxation time and myocardial performance index (MPI). It also exhibited decreased early diastolic velocity (Em) and a decreased mitral annular displacement index in these patients. There were positive correlations between the LV lateral wall MPI (r = 0.231), septal MPI (r = 0.223), and LV mass index (p < 0.05) but no correlation with the duration of AED treatment. The authors detected subclinical ventricular dysfunction associated with AEDs at a preclinical stage. They suggest that TDI can be useful for determining the short- and long-term cardiac effects of AEDs.
dc.identifier.citationKIBAR A. E. , UNVER O., OFLAZ M. B. , GÜVEN A. S. , BALLI S., Ece I., ERDEM S., İÇAĞASIOĞLU F. D. , -Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study-, PEDIATRIC CARDIOLOGY, cilt.35, ss.280-288, 2014
dc.identifier.doi10.1007/s00246-013-0771-8
dc.identifier.scopus84893657959
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27091
dc.identifier.wosWOS:000330621300012
dc.titleEffect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide7fa47a1-51e9-434d-94c3-9c383273eb30
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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