Publication:
Standard Water Generating Vials for Lipophilic Compounds

dc.contributor.authorDincel D.
dc.contributor.authorRosales-Solano H.
dc.contributor.authorZeinali S.
dc.contributor.authorPawliszyn J.
dc.contributor.institutionauthorDİNCEL, DEMET
dc.date.accessioned2023-02-01T21:31:21Z
dc.date.available2023-02-01T21:31:21Z
dc.date.issued2023-01-17
dc.description.abstractAmerican Chemical Society.The study of non-polar compounds in aqueous environments has always been challenging due to their poor solubility in aqueous media. The low affinity of non-polar compounds toward polar solutions facilitates their attachment to glassware, which results in unstable sample concentrations. To address this challenge, and to enable the preparation of a stable mixture of hydrophobic compounds in an aquatic environment, we introduce an in-vial standard water generating system consisting of a vial containing appropriate aqueous solution and a polydimethylsiloxane thin film spiked with target compounds. In this system, a solution with a stable analyte concentration is attained once equilibrium between the thin-film and aqueous solution has been achieved. The developed standard water system was studied using endocannabinoids and phospholipids as model hydrophobic compounds of biological importance, with results indicating that the concentration of hydrophobic compounds in water can remain stable over multiple days. The results also showed that analytes released from the thin film can compensate for analyte loss due to extractions with solid-phase microextraction fibers, thereby re-establishing equilibrium. Thus, the vial is suitable for the repeatable generation of non-polar standards for routine analysis and quality control. The results of this work show that the developed system is stable and reproducible and therefore appropriate for studies requiring the measurement of free concentrations and accurate quantification.
dc.identifier.citationDincel D., Rosales-Solano H., Zeinali S., Pawliszyn J., "Standard Water Generating Vials for Lipophilic Compounds", Analytical Chemistry, cilt.95, sa.2, ss.820-826, 2023
dc.identifier.doi10.1021/acs.analchem.2c02993
dc.identifier.endpage826
dc.identifier.issn0003-2700
dc.identifier.issue2
dc.identifier.pubmed36546835
dc.identifier.startpage820
dc.identifier.urihttps://hdl.handle.net/20.500.12645/35154
dc.identifier.volume95
dc.relation.ispartofAnalytical Chemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectAnalytical Chemistry
dc.subjectNatural Sciences
dc.subjectTemel Bilimler (SCI)
dc.subjectKİMYA, ANALİTİK
dc.subjectNatural Sciences (SCI)
dc.subjectCHEMISTRY
dc.subjectCHEMISTRY, ANALYTICAL
dc.subjectFizik Bilimleri
dc.subjectPhysical Sciences
dc.titleStandard Water Generating Vials for Lipophilic Compounds
dc.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublication175ac1d2-5098-48b0-b640-bc5d436ea25c
relation.isAuthorOfPublication.latestForDiscovery175ac1d2-5098-48b0-b640-bc5d436ea25c
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