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Ferulago blancheana bitkisindeki sekonder metabolitlerin izolasyonu, antioksidan ve antikolinesteraz aktivitelerinin incelenmesi

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dc.contributor.advisorTopçu, Gülaçtı
dc.contributor.authorAslan, Esin
dc.date.accessioned2020-07-14T14:16:44Z
dc.date.available2020-07-14T14:16:44Z
dc.date.issued2016en
dc.descriptionThesis (Master)--Bezmialem Vakıf University, Department of Pharmacognosy, Istanbul, 2016en
dc.description.abstractThe Ferulago is an aromatic (fragrant) plant, which is a member of one of the flowering plant families, the Apiaceae (=Umbelliferae). The Ferulago and its similar species are known as the "giant fennel" (Çakşır, Çağşır); it is used by people traditionally to soothe the nervous system, relieve gas, get rid of worms, and its roots are separately used as an aphrodisiac. The Ferulago blancheana Post which is currently being worked on, is an endemic species that grows in Kahramanmaraş Başkonuş (Square C6). The Ferulago blancheana was first introduced to the scientific world in Boisser's work "Flora Orientalis Supplementum" which was published in 1888. Until today, in Turkey and the world, the Ferulago species have mostly been worked for their volatile oils and some activities, in general. The Ferulago species, as well as having very little work done in terms of its isolation and other metabolites, the Ferulago blancheana is being worked on for the first time in terms of its volatile oil, isolation, and the use of secondary metabolites. In this thesis study, eight compounds have been isolated from Ferulago blancheana plant. In the first stage, the Ferulago blancheana plant's dichloromethane and ethyl acetate /methanol extracts were prepared. After the total phenolics amount and the total flavanoids amount were accounted to as equal to quercetin, and antioxidant activities were detected by inhibition of lipid peroxidation and DPPH free radical scavenging methods. Dichloromethane and ethyl acetate/methanol extracts of Ferulago blancheana and the anticholinesterase activities of the pure compounds isolated were identified using the Ellman method against the AChE and BChE enzymes. As the main secondary metabolites of the exracts coumarins, and five furanocoumarin, and two steroids structure isolated and purified; their structures were identified using spectroscopic (NMR, UV) methods. Keywords: Ferulago blancheana; furanocoumarin; antioxidant activity; anticholinesterase activity; heraclenol; imperatorin This research was supported by the Scientific Research Unit of Bezmialem Vakıf University. Project No: 9.2014/17en
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18199
dc.language.isoenen
dc.publisherBezmialem Vakıf Universityen
dc.subjectEczacılık ve Farmakoloji = Pharmacy and Pharmacologytr_TR
dc.subjectAntioksidanlar = Antioxidantstr_TR
dc.subjectApiaceae = Apiaceaetr_TR
dc.subjectFarmakognozi = Pharmacognosytr_TR
dc.subjectFerulagotr_TR
dc.subjectFurokumarinler = Furocoumarinstr_TR
dc.subjectKolinesterazlar = Cholinesterasestr_TR
dc.subjectMetabolitler = Metabolitestr_TR
dc.titleFerulago blancheana bitkisindeki sekonder metabolitlerin izolasyonu, antioksidan ve antikolinesteraz aktivitelerinin incelenmesitr_TR
dc.typeThesis Masteren
dc.typeThesis Master
dspace.entity.typePublication
local.thesis.programnameDepartment of Pharmacognosyen
local.thesis.termBahar Dönemitr_TR
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