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GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.

dc.contributor.authorERKOÇ, R
dc.contributor.authorÇıKRıKÇıOĞLU, MA
dc.contributor.authorAINTAB, E
dc.contributor.authorTOPRAK, ALİ
dc.contributor.authorKILIC, U
dc.contributor.authorGOK, O
dc.contributor.authorCETIN, AI
dc.contributor.authorZORLU, MEHMET
dc.contributor.authorKıSKAÇ, MUHARREM
dc.contributor.authorCAKIRCA, MUSTAFA
dc.contributor.authorKaratoprak, CUMALİ
dc.contributor.authorISEN, HC
dc.contributor.institutionauthorZORLU, MEHMET
dc.contributor.institutionauthorKISKAÇ, MUHARREM
dc.contributor.institutionauthorÇAKIRCA, MUSTAFA
dc.contributor.institutionauthorKARATOPRAK, CUMALİ
dc.date.accessioned2019-10-05T13:30:57Z
dc.date.available2019-10-05T13:30:57Z
dc.date.issued2015-06-01
dc.description.abstractBackground - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
dc.identifier
dc.identifier.citationERKOÇ R., ÇıKRıKÇıOĞLU M., AINTAB E., TOPRAK A., KILIC U., GOK O., CETIN A., ZORLU M., KıSKAÇ M., CAKIRCA M., et al., -GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.-, Renal failure, cilt.37, ss.866-70, 2015
dc.identifier.doi10.3109/0886022x.2015.1034606
dc.identifier.pubmed25869052
dc.identifier.scopus84941054075
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2268
dc.identifier.urihttps://www.tandfonline.com/loi/irnf20
dc.identifier.wosWOS:000361338400021
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdiabetic nephropathy
dc.titleGAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameNOBEL MEDICUS
local.avesis.id3711ea91-9ac1-4b0d-a91c-3542b85b99b6
local.avesis.response2138
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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