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Oxidative Stress and Antioxidant Enzyme Activities in Newborns with Oesophageal Atresia and Their Mothers

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dc.contributor.authorMelek, M.
dc.contributor.authorDemir, Halit
dc.contributor.authorBilici, S.
dc.contributor.authorBeger, Burhan
dc.contributor.authorÇobanoğlu, Ufuk
dc.contributor.authorMeral, I.
dc.contributor.authorKeskin, Seda
dc.contributor.authorOzmen, E.
dc.contributor.institutionauthorMERAL, İSMAİL
dc.date.accessioned2020-10-29T20:39:23Z
dc.date.available2020-10-29T20:39:23Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractOBJECTIVE: To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects. METHODS: This case control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10 healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured. RESULTS: MDA levels and CA activity were significantly higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in newborns than in mothers in the healthy group. CONCLUSIONS: Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal atresia.
dc.identifier.citationMelek M., Demir H., Bilici S., Beger B., Çobanoğlu U., Meral I., Keskin S., Ozmen E., -Oxidative Stress and Antioxidant Enzyme Activities in Newborns with Oesophageal Atresia and Their Mothers-, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.40, ss.249-257, 2012
dc.identifier.doi10.1177/147323001204000125
dc.identifier.scopus84857892352
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26142
dc.identifier.wosWOS:000302272300025
dc.titleOxidative Stress and Antioxidant Enzyme Activities in Newborns with Oesophageal Atresia and Their Mothers
dc.typeArticle
dspace.entity.typePublication
local.avesis.id753ef806-7e6e-45b9-98ce-45fe59ed7505
local.publication.isinternational1
relation.isAuthorOfPublication58058ee9-1440-480c-9817-c6b25d7ec008
relation.isAuthorOfPublication.latestForDiscovery58058ee9-1440-480c-9817-c6b25d7ec008
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