Publication:
In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.

dc.contributor.authorGünes-Bayir, A
dc.contributor.authorKocyigit, A
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorDadak, A
dc.contributor.institutionauthorGÜNEŞ BAYIR, AYŞE
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.date.accessioned2020-08-07T20:59:11Z
dc.date.available2020-08-07T20:59:11Z
dc.date.issued2020-07-17T00:00:00Z
dc.description.abstractThe concept of hormesis includes a biphasic cellular dose-response to a xenobiotic stimulus defined by low dose beneficial and high dose inhibitory or toxic effects. In the present study, an attempt has been made to help elucidate the beneficial and detrimental effects of thymol on different cell types by evaluating and comparing the impact of various thymol doses on cancerous (AGS) and healthy (WS-1) cells. Cytotoxic, genotoxic, and apoptotic effects, as well as levels of reactive oxygen species and glutathione were studied in both cell lines exposed to thymol (0-600 mu M) for 24 h. The results showed significant differences in cell viability of AGS compared to WS-1 cells exposed to thymol. The differences observed were statistically significant at all doses applied (P <= 0.001) and revealed hormetic thymol effects on WS-1 cells, whereas toxic effects on AGS cells were detectable at all thymol concentrations. Thymol at low concentrations provides antioxidative protection to WS-1 cells in vitro while already inducing toxic effects in AGS cells. In that sense, the findings of the present study suggest that thymol exerts a dose-dependent hormetic impact on different cell types, thereby providing crucial information for future in vivo studies investigating the therapeutic potential of thymol.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationGünes-Bayir A., Kocyigit A., Guler E. M. , Dadak A., -In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.-, Molecules (Basel, Switzerland), cilt.25, 2020
dc.identifier.doi10.3390/molecules25143270
dc.identifier.pubmed32709059
dc.identifier.scopus85088682689
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18330
dc.identifier.urihttps://www.mdpi.com/1420-3049/25/14/3270
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThymol
dc.subjectHealthy cells
dc.titleIn Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.
dc.typeArticle
dspace.entity.typePublication
local.avesis.idef1de177-63c7-425e-b412-27623f855e16
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery5e36f185-4cd3-4406-997c-fbc22d54053f
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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