Publication:
The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer's Disease and Its Molecular Mechanism

dc.contributor.authorDURAN, RABİA
dc.contributor.authorPancur, Sumeyra
dc.contributor.authorBAHADORİ, FATEMEH
dc.contributor.institutionauthorDURAN, RABİA
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.date.accessioned2022-02-08T20:59:20Z
dc.date.available2022-02-08T20:59:20Z
dc.date.issued2022-01-01T00:00:00Z
dc.description.abstractFollowing increased epidemiological studies indicating the relationship between diabetes and Alzheimer-s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology. Insulin resistance that develops in the brain, impairment in the insulin signal delivery system and glucose metabolism have been shown among the most likely pathophysiological causes of AD. It has been reported that the increase in AD markers such as phospho tau and A beta in the type 2 diabetes model of rats is associated with the decrease in the insulin receptor (IR) signaling and insulin-like growth factor-1 receptors (IGF-1R) ratio. Furthermore, intracellular components such as phospho-AKT (protein kinase B) and phospho-glycogen synthase kinase-3 beta (GSK3 beta), which are members of IR pathway, have been proved to be reduced in AD. Due to the common molecular mechanisms underlying the pathological development of Type 2 Diabetes and AD, treatment protocols indicated in diabetes have been used in the treatment of AD.
dc.identifier.citationDuran R, Pancur S, Bahadori F. The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism. Bezmialem Science 2022;10(1):114-22
dc.identifier.doi10.14235/bas.galenos.2020.4491
dc.identifier.trdizin1170984
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30385
dc.identifier.wosWOS:000748399400020
dc.subjectDiabetes
dc.subjectAlzheimer’s
dc.subjectIR
dc.subjectIGF-1R
dc.subjectp-AKT
dc.subjectGSK3β
dc.subjectamyloid β
dc.subjecttau
dc.titleThe Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer's Disease and Its Molecular Mechanism
dc.typeArticle
dspace.entity.typePublication
local.avesis.idc35dac05-32ab-47ff-a0d0-d672ef0a3904
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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