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Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats

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dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorERDOĞAN, MEHMET ALİ
dc.contributor.authorSahin, NURHAN
dc.contributor.authorPARLAKPINAR, HAKAN
dc.contributor.authorAtayan, Yahya
dc.contributor.authorPOLAT, ALAADİN
dc.contributor.authorVARDI, NİGAR
dc.contributor.authorYILDIZ, AZİBE
dc.contributor.authorTANBEK, KEVSER
dc.contributor.institutionauthorŞAHİN, NURHAN
dc.date.accessioned2020-10-22T20:17:37Z
dc.date.available2020-10-22T20:17:37Z
dc.date.issued2015-10-01T00:00:00Z
dc.description.abstractBackground and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that cisplatin-induced hepatotoxicity is caused by oxidative stress resulting from increased reactive oxygen species (ROS). Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of cisplatin on hepatic pro-oxidant/antioxidant systems and to investigate protective effects of APO against cisplatin-induced hepatotoxicity.
dc.identifier.citationCagin Y. F. , ERDOĞAN M. A. , Sahin N., PARLAKPINAR H., Atayan Y., POLAT A., VARDI N., YILDIZ A., TANBEK K., -Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats-, ARCHIVES OF MEDICAL RESEARCH, cilt.46, ss.517-526, 2015
dc.identifier.doi10.1016/j.arcmed.2015.08.005
dc.identifier.scopus84946063461
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24595
dc.identifier.wosWOS:000366145800001
dc.titleProtective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd00924c7-1945-4a8a-a6d6-2dd558dbb9e8
local.indexed.atWOS
local.indexed.atScopus
local.publication.isinternational1
relation.isAuthorOfPublication84f8cc2e-0a04-41e1-b473-7f2af3f72119
relation.isAuthorOfPublication.latestForDiscovery84f8cc2e-0a04-41e1-b473-7f2af3f72119

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