Publication:
Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans

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dc.contributor.authorTuncer, Ilyas
dc.contributor.authorHarman, Mustafa
dc.contributor.authorColak, Yasar
dc.contributor.authorArslan, Ismail
dc.contributor.authorTurkdogan, M. Kursad
dc.date.accessioned2020-10-22T18:33:03Z
dc.date.available2020-10-22T18:33:03Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractBackground/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (n = 22) was given UDCA (15 mg/kg/day) alone and group II (n = 18) was treated with domperidone (30 mg/day) in addition to UDCA. The control group (n = 13) was followed without a medical treatment. Gallbladder volumes and ejection fractions were measured sonographically in all patients before and after treatment. Results. After 12 months of treatment, stone dissolution was found in 9 (40.9%) of the patients in group I and 7 (38.8%) of the patients in group II. The difference was statistically significant compared to controls in both treatment groups (P 0.05). All the patients that achieved dissolution had multiple gallstones except for one patient with a solitary stone in group I. Neither monotherapy of UDCA nor the combination with domperidone affected the ejection fraction of gallbladder. Conclusions. Combination with domperidone did not potentiate the efficacy of UDCA. It has been observed that both UDCA alone and UDCA plus domperidone treatment did not affect ejection fraction of gallbladder.
dc.identifier.citationTuncer I., Harman M., Colak Y., Arslan I., Turkdogan M. K. , -Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans-, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2012
dc.identifier.doi10.1155/2012/159438
dc.identifier.scopus84862282580
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24139
dc.identifier.wosWOS:000304981600001
dc.subjectdrugs
dc.titleEffect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8aa8a60d-755c-4056-ad0b-cb8a593be202
local.publication.isinternational1
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