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Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul.

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dc.contributor.authorCeylan, AN
dc.contributor.authorTurkmen, AV
dc.contributor.authorTurel, O
dc.contributor.authorGultepe, BİLGE
dc.contributor.authorInan, E
dc.contributor.authorDoymaz, MEHMET ZİYA
dc.contributor.institutionauthorTÜREL, ÖZDEN
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorDOYMAZ, MEHMET ZIYA
dc.date.accessioned2019-11-03T22:35:30Z
dc.date.available2019-11-03T22:35:30Z
dc.date.issued2019-01-01
dc.description.abstractHand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient's samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks. Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient’s samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks.
dc.identifier.citationCeylan A., Turel O., Gultepe B., Inan E., Turkmen A., Doymaz M. Z. , -Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul.-, Polish journal of microbiology, cilt.68, ss.165-171, 2019
dc.identifier.doi10.21307/pjm-2019-016
dc.identifier.pubmed31257789
dc.identifier.scopus85068981042
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10254
dc.identifier.wosWOS:000472989400002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleHand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id082e1525-5fc0-4c78-b415-7e22eb45f03a
local.org.facultyTıp Fakültesi
local.publication.isinternational1
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relation.isAuthorOfPublication51568f47-69f1-46a2-b201-e6d6161080a8
relation.isAuthorOfPublicationb68333b8-8b35-4545-989f-bf6e27e7a81b
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