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Multiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate

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dc.contributor.authorChatterjee, Aritrick
dc.contributor.authorTOKDEMİR, SEVİL
dc.contributor.authorGallan, Alexander J.
dc.contributor.authorYousuf, Ambereen
dc.contributor.authorAntic, Tatjana
dc.contributor.authorKarczmar, Gregory S.
dc.contributor.authorOto, Aytekin
dc.contributor.institutionauthorTOKDEMİR, SEVİL
dc.date.accessioned2020-10-22T18:31:51Z
dc.date.available2020-10-22T18:31:51Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractOBJECTIVE. This study investigates the multiparametric MRI (mpMRI) characteristics and pathologic outcome of wedge-shaped lesions observed on T2-weighted images. MATERIALS AND METHODS. Seventy-six patients with histologically confirmed prostate cancer underwent preoperative 3-T MRI before undergoing radical prostatectomy. Two radiologists worked in consensus to mark wedge-shaped regions of hypointensity on T2-weighted images and assess their appearance on apparent diffusion coefficient (ADC) maps (to determine the degree of hypointensity) and dynamic contrast-enhanced (DCE) MRI (DCE-MRI) (to assess whether they showed early enhancement). The pathologic outcome of wedge-shaped lesions was assessed by matching MR images with whole-mount histologic specimens retrospectively. The difference in quantitative ADC values between malignant and benign wedge-shaped lesions was assessed using a t test. RESULTS. Thirty-five wedge-shaped regions were identified, 12 (34%) of which were found be malignant. Most malignant wedge-shaped regions were highly hypointense (10/12; 83%) on ADC maps and showed early enhancement on DCE-MRI (7/12; 58%). However, benign wedge-shaped lesions were predominantly mildly hypointense (13/23; 57%) on ADC maps and showed no early enhancement (15/23; 65%). Histologic correlates of the benign wedge-shaped regions showed prostatitis (acute inflammation [7/23; 30%] or chronic inflammation [9/23; 39%]), hemosiderin-laden macrophages (6/23; 26%), prominent blood vessels (7/23; 30%), intraluminal blood (6/23; 26%), and nonspecific atrophy (6/23; 26%). The mean (± SD) quantitative ADC value of malignant wedge-shaped regions (1.13 ± 0.11 μm2/ms) was significantly lower (p = 0.0001) than that of benign wedge-shaped regions (1.52 ± 0.27 μm2/ms). CONCLUSION. This study shows that a greater percentage of wedge-shaped features are malignant than was previously thought. Of importance, mpMRI (specifically, ADC maps) can distinguish between malignant and benign wedge-shaped features.
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dc.identifier.citationChatterjee A., TOKDEMİR S., Gallan A. J. , Yousuf A., Antic T., Karczmar G. S. , Oto A., -Multiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate-, AMERICAN JOURNAL OF ROENTGENOLOGY, cilt.212, ss.124-129, 2019
dc.identifier.doi10.2214/ajr.18.19742
dc.identifier.pubmed30403532
dc.identifier.scopus85058902292
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24090
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437777/
dc.identifier.wosWOS:000453925000025
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApparent diffusion coefficient
dc.subjectHistology
dc.titleMultiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8398914c-57b9-4cac-bfe0-b28dbc275979
local.publication.isinternational1
relation.isAuthorOfPublicationd1106f25-da55-4fab-9420-0e9cb1a0d387
relation.isAuthorOfPublication.latestForDiscoveryd1106f25-da55-4fab-9420-0e9cb1a0d387
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