Management of myxopapillary ependymoma: a retrospective study from three institutions

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Abdallah, Anas
Baloglu, Gokhan
Abdallah, Betul Guler
Papaker, Meliha Gundag
Rakip, Usame
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Background: Myxopapillary ependymomas (MPEs) possess leptomeningeal, neural axis dissemination, seeding metastases, and extra-neural spread which are malignant characteristics, even they classified low-grade lesions as WHO grade II. Managing such lesions remains an arguable neurosurgical challenge. The study aimed to discuss the management of MPEs by evaluating the long-term surgical outcomes of consecutively treated MPEs in different 3 neurosurgical centers. Methods: Medical records of all diagnosed patients with spinal tumors at our institutions were reviewed retrospectively. This study included all consecutive MPE who underwent surgical intervention in our institutions in different periods between February 2004 and December 2020. Results: A total of 44 patients with MPE were treated surgically in three institutions. 28 (63.6%) patients were males. Six patients were pediatric patients (2 segments, unclear boundaries, bone-erosions were associated with poor prognosis and progression. Laminectomy and surgical complications were associated with poor functional outcomes. En bloc resection without violation of lesions- integrities reduced the progression. Conclusions: Radiological, intraoperative, and surgical factors can affect the functional outcomes and the progression of MPEs. Some precautions in the surgical interventions particularly in MPEs with defined radiological features can improve functional outcomes and reduce the progression risk.
Abdallah A., Baloglu G., Abdallah B. G. , Papaker M. G. , Rakip U., -Management of myxopapillary ependymoma: a retrospective study from three institutions-, NEUROLOGICAL RESEARCH, 2022
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