Publication:
Chemical profile and biological activities of Veronica thymoides subsp pseudocinerea

dc.contributor.authorErtas, Abdulselam
dc.contributor.authorBoga, Mehmet
dc.contributor.authorKizil, Murat
dc.contributor.authorCeken, Bircan
dc.contributor.authorGOREN, AHMET CEYHAN
dc.contributor.authorHasimi, Nesrin
dc.contributor.authorDemirci, Serpil
dc.contributor.authorTopcu, GÜLAÇTI
dc.contributor.authorKolak, Ufuk
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2019-10-05T15:19:10Z
dc.date.available2019-10-05T15:19:10Z
dc.date.issued2015-03-01
dc.description.abstractContext: In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. Objective: To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis subsp. pseudocinerea M.A. Fischer as a potential source of natural active compounds. Materials and methods: GC/MS was used to analyze essential oil and fatty acid obtained from whole plant. The antioxidant activity was evaluated by the beta-carotene-linoleic acid test system, DPPH-free and ABTS cation radicals scavenging, and cupric reducing antioxidant capacity assays. The anticholinesterase and antimicrobial activities were determined by Ellman and broth macrodillution methods, respectively. The effect of the methanol extract on DNA cleavage was investigated. Results: Hexatriacontene (21.0%) was found to be the main constituent in essential oil, and linoleic acid (25.2%) and palmitic acid (20.6%) in fatty acid. Methanol extract demonstrated the best IC50 values in lipid peroxidation (49.81 +/- 0.31 mu g/ml) and DPPH-free radical scavenging activity (15.32 +/- 0.17 mu g/ml). Methanol and water extracts possessed strong ABTS cation radical scavenging activity with IC50 values 9.15 +/- 0.28 and 8.90 +/- 0.14 mu g/ml, respectively. The acetone extract exhibited moderate butyrylcholinesterase inhibitory activity. The highest antimicrobial activity was determined in methanol extract against Escherichia coli with 31.25 mu g/ml MIC value. Inhibition of methanol extract on plasmid DNA cleavage by OH radicals was found to be 93.32% at 500 mu g/ml. Conclusion: The methanol extract having strong antioxidant and DNA damage effects could be investigated phytochemically to find natural active compounds.
dc.identifier
dc.identifier.citationErtas A., Boga M., Kizil M., Ceken B., GOREN A. C. , Hasimi N., Demirci S., Topcu G., Kolak U., -Chemical profile and biological activities of Veronica thymoides subsp pseudocinerea-, PHARMACEUTICAL BIOLOGY, cilt.53, ss.334-339, 2015
dc.identifier.pubmed
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5986
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/13880209.2014.919326
dc.identifier.wosWOS:000348831200004
dc.language.isoen
dc.subjectAnticholinesterase
dc.titleChemical profile and biological activities of Veronica thymoides subsp pseudocinerea
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameÇağdaş Cerrahi Dergisi
local.avesis.id948c0a13-aca1-4af0-914f-545a9aa5ac9f
local.avesis.response5856
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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