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The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group.

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dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorCebeci, Egemen
dc.contributor.authorTurkmen, Aydin
dc.contributor.authorDerici, Ulver
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorEren, Necmi
dc.contributor.authorDede, Fatih
dc.contributor.authorGullulu, Mustafa
dc.contributor.authorBasturk, Taner
dc.contributor.authorSahin, Gulizar Manga
dc.contributor.authorYilmaz, Murvet
dc.contributor.authorSipahi, Savas
dc.contributor.authorSahin, Garip
dc.contributor.authorUlu, Sena
dc.contributor.authorTatar, Erhan
dc.contributor.authorGundogdu, Ali
dc.contributor.authorKazancioglu, Rümeyza
dc.contributor.authorSevinc, Can
dc.contributor.authorGungor, Ozkan
dc.contributor.authorSahin, İdris
dc.contributor.authorKutlay, Sim
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorAydin, Zeki
dc.contributor.authorAltun, Bulent
dc.contributor.authorDursun, Belda
dc.contributor.authorYilmaz, Zulfikar
dc.contributor.authorUzun, Ozcan
dc.contributor.authorSuleymanlar, Gultekin
dc.contributor.authorCandan, Ferhan
dc.contributor.authorSezer, Siren
dc.contributor.authorTanburoglu, Derya Basak
dc.contributor.authorBahcebasi, Zerrin Bicik
dc.contributor.authorTaymez, Dilek
dc.contributor.authorAkcali, Esra
dc.contributor.authorOygar, Deren
dc.contributor.authorIstemihan, Zulal
dc.contributor.authorBardak, Simge
dc.contributor.authorAkcay, Omer Faruk
dc.contributor.authorDincer, Mevlut Tamer
dc.contributor.authorDervisoglu, Erkan
dc.contributor.authorYenigun, Ezgi
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorOzturk, Savas
dc.contributor.institutionauthorKAZANCIOĞLU, RÜMEYZA
dc.date.accessioned2021-10-30T20:59:06Z
dc.date.available2021-10-30T20:59:06Z
dc.date.issued2021-10-28T00:00:00Z
dc.description.abstractBackground: Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods: A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results: 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion: Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.
dc.identifier.citationTurgutalp K., Cebeci E., Turkmen A., Derici U., Seyahi N., Eren N., Dede F., Gullulu M., Basturk T., Sahin G. M. , et al., -The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group.-, BMC nephrology, cilt.22, sa.1, ss.352, 2021
dc.identifier.doi10.1186/s12882-021-02560-2
dc.identifier.pubmed34711174
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29603
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group.
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida494029c-01a0-401b-be41-acbe0b02b8e6
local.publication.isinternational1
relation.isAuthorOfPublicationeca7bd30-6b6e-444d-96ae-2961c39f2107
relation.isAuthorOfPublication.latestForDiscoveryeca7bd30-6b6e-444d-96ae-2961c39f2107
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