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Enzyme inhibitory and antioxidant activity of Melia azedarach L. naturalized in Anatolia and its phenolic acid and fatty acid composition

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dc.contributor.authorOrhan, I. Erdogan
dc.contributor.authorGuner, E.
dc.contributor.authorOzturk, N.
dc.contributor.authorSenol, F. S.
dc.contributor.authorErdem, S. Aslan
dc.contributor.authorKartal, MURAT
dc.contributor.authorSener, B.
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-10-29T21:10:18Z
dc.date.available2020-10-29T21:10:18Z
dc.date.issued2012-05-01T00:00:00Z
dc.description.abstractIn the present study, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase inhibitory and antioxidant activities of the fruit and leaf extracts of Melia azedarach L (Meliaceae) of Turkish origin were evaluated. Enzyme inhibitory activity of the extracts was tested in vitro using ELISA microplate reader. Antioxidant activity of the extracts was tested using 2,2-dipheny1-1-picrylhydrazyl (DPPH) radical scavenging, ferrous ion-chelation, and ferric-reducing antioxidant power (FRAP) assays. Phenolic composition of the extracts was elucidated by high performance liquid chromatography (HPLC) and fatty acid compositions of the fatty oils of the fruits and leaves were elucidated by gas chromatography-mass spectrometry (GC-MS). The ethyl acetate extract from the leaves showed the highest inhibition against AChE (33.63 +/- 1.40%) and BChE (92.89 +/- 3.05%). The methanol extract from the leaves exerted the best antioxidant activity in DPPH radical scavenging and FRAP assays, while the ethyl acetate extracts of the fruits and leaves had the most notable effect in metal-chelation assay. (C) 2011 Elsevier B.V. All rights reserved.
dc.identifier.citationOrhan I. E. , Guner E., Ozturk N., Senol F. S. , Erdem S. A. , Kartal M., Sener B., -Enzyme inhibitory and antioxidant activity of Melia azedarach L. naturalized in Anatolia and its phenolic acid and fatty acid composition-, INDUSTRIAL CROPS AND PRODUCTS, cilt.37, ss.213-218, 2012
dc.identifier.doi10.1016/j.indcrop.2011.11.028
dc.identifier.scopus84855447576
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26186
dc.identifier.wosWOS:000301906100030
dc.titleEnzyme inhibitory and antioxidant activity of Melia azedarach L. naturalized in Anatolia and its phenolic acid and fatty acid composition
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7c16008b-43f1-43ef-8c57-b855f56980bb
local.publication.isinternational1
relation.isAuthorOfPublicationb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
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