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Effects of Hyaluronic Acid and Hydroxyapatite/Beta-tricalcium Phosphate in Combination on Bone Regeneration of a Critical-size Defect in an Experimental Model

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dc.contributor.authorDiker, NURETTİN
dc.contributor.authorGulsever, Serap
dc.contributor.authorKoroglu, Taner
dc.contributor.authorAkcay, Eda Yilmaz
dc.contributor.authorOguz, Yener
dc.contributor.institutionauthorDİKER, NURETTİN
dc.date.accessioned2020-10-29T14:43:33Z
dc.date.available2020-10-29T14:43:33Z
dc.date.issued2018-06-01T00:00:00Z
dc.description.abstractHyaluronic acid (HyA) is an outstanding new product in the field of oral and maxillofacial surgery. The aim of this study was to evaluate the effects of HyA on bone regeneration in critical-size calvarial defects. Twenty-four female Sprague-Dawley rats were used in the present study. In each rat, 4 critical-size defects received different treatments: no treatment (control); HyA; Graft; and HyA+Graft combination. New bone formation, defect closure, inflammation, vascular proliferation, immature bone formation, mature bone formation, and bone marrow existence were investigated based on histological findings. The healing parameters related to bone formation (new bone formation, defect closure, immature bone formation) were significantly higher in the HyA group compared with the control group. However, HyA alone was unable to induce sufficient bone regeneration compared with treatments involving graft materials (Graft and HyA+Graft). In the Graft and HyA+Graft groups, prominent enhancement of all healing parameters was noted. The present results demonstrate that HyA alone did not adequately enhance bone regeneration in critical-size defects. Moreover, addition of HyA to a biphasic alloplastic graft material did not result in improved regeneration compared with the graft material alone.
dc.identifier.citationDiker N., Gulsever S., Koroglu T., Akcay E. Y. , Oguz Y., -Effects of Hyaluronic Acid and Hydroxyapatite/Beta-tricalcium Phosphate in Combination on Bone Regeneration of a Critical-size Defect in an Experimental Model-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.29, ss.1087-1093, 2018
dc.identifier.doi10.1097/scs.0000000000004338
dc.identifier.scopus85047003671
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25405
dc.identifier.wosWOS:000434304300099
dc.titleEffects of Hyaluronic Acid and Hydroxyapatite/Beta-tricalcium Phosphate in Combination on Bone Regeneration of a Critical-size Defect in an Experimental Model
dc.typeArticle
dspace.entity.typePublication
local.avesis.id2aacd5fc-1ccf-4f6d-93f0-0b0c2fab6e89
local.publication.isinternational1
relation.isAuthorOfPublicationaad04544-dd5e-45d4-a15d-24365e416f6e
relation.isAuthorOfPublication.latestForDiscoveryaad04544-dd5e-45d4-a15d-24365e416f6e
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