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Nitric oxide synthase inhibitors protect cerebellar Purkinje cells from zinc-induced cell loss in adult rat

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dc.contributor.authorGokce, Mehmet Fatih
dc.contributor.authorKAPLAN, Süleyman
dc.contributor.authorTurkkani, Ayten
dc.contributor.authorKozan, Ramazan
dc.contributor.authorAYYILDIZ, MUSTAFA
dc.contributor.authorEMİRZEOĞLU, MEHMET
dc.contributor.authorASLAN, HÜSEYİN
dc.contributor.authorMARANGOZ, CAFER
dc.date.accessioned2020-10-22T18:54:00Z
dc.date.available2020-10-22T18:54:00Z
dc.date.issued2011-01-01T00:00:00Z
dc.description.abstractZinc is an important trace element in biological systems; however, excessive extracellular zinc could lead to neuronal cell death following ischemia, seizures, and brain trauma. In this study, we investigated whether the intracortical injection of zinc sulphate (200 mu g/kg, i.c.) changes total number of Purkinje cells in the cerebellum and whether different types nitric oxide synthase inhibitors. N-(G)-nitro-L-arginine methyl ester (L-NAME), N(omega)-nitro-L-arginine (L-NNA), aminoguanidine and 7-nitroindazole (7-NI), have protective effects against zinc neurotoxicity in Wistar albino rat;. Animals were divided into 6 groups: control, zinc, zinc + L-NAME (100 mg/kg, i.p.), zinc + L-NNA (100 mg/kg, i.p.), zinc + 7-NI (100 mg/kg, i.p.) and zinc + aminoguanidine (100 mg/kg, i.p.) groups. Total number of Purkinje cells in the cerebellum was estimated using unbiased stereological technique as 318,947 +/- 20,549, 123,483 +/- 23,762, 206,537 +/- 43,128, 178,135 +/- 26,635, 193,148 +/- 46,104 and 212,910 +/- 26,399 in the control, zinc, zinc + L-NAME, zinc + L-NNA, zinc + 7-NI and zinc + aminoguanidine groups, respectively (mean +/- SD). The number of Purkinje cells in zinc group was significantly lower than that of the other groups (P < 0.001). It was found that the nitric oxide synthase inhibitors have neuroprotective effect against zinc neurotoxicity on Purkinje cells. These data show that the inhibition of the nitric oxide synthase could prevent some of the deleterious effects of zinc on Purkinje cells. (C) 2010 Elsevier B.V. All rights reserved.
dc.identifier.citationGokce M. F. , KAPLAN S., Turkkani A., Kozan R., AYYILDIZ M., EMİRZEOĞLU M., ASLAN H., MARANGOZ C., -Nitric oxide synthase inhibitors protect cerebellar Purkinje cells from zinc-induced cell loss in adult rat-, JOURNAL OF CHEMICAL NEUROANATOMY, cilt.41, ss.25-31, 2011
dc.identifier.doi10.1016/j.jchemneu.2010.10.004
dc.identifier.scopus78650250152
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24319
dc.identifier.wosWOS:000287074900004
dc.titleNitric oxide synthase inhibitors protect cerebellar Purkinje cells from zinc-induced cell loss in adult rat
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida1b29d70-7f04-48e6-aa49-730530034927
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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